Drug resistance in leishmaniasis
Leishmaniasis is a complex disease, with visceral and cutaneous manifestations, and is
caused by over 15 different species of the protozoan parasite genus Leishmania. There are …
caused by over 15 different species of the protozoan parasite genus Leishmania. There are …
Leishmaniasis: current status of available drugs and new potential drug targets
The control of Leishmania infection relies primarily on chemotherapy till date. Resistance to
pentavalent antimonials, which have been the recommended drugs to treat cutaneous and …
pentavalent antimonials, which have been the recommended drugs to treat cutaneous and …
Pentavalent antimonials: new perspectives for old drugs
F Frézard, C Demicheli, RR Ribeiro - Molecules, 2009 - mdpi.com
Pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate,
have been used for more than half a century in the therapy of the parasitic disease …
have been used for more than half a century in the therapy of the parasitic disease …
Use of antimony in the treatment of leishmaniasis: current status and future directions
In the recent past the standard treatment of kala‐azar involved the use of pentavalent
antimonials Sb (V). Because of progressive rise in treatment failure to Sb (V) was limited its …
antimonials Sb (V). Because of progressive rise in treatment failure to Sb (V) was limited its …
Leishmaniasis: drugs in the clinic, resistance and new developments
M Ouellette, J Drummelsmith, B Papadopoulou - Drug Resistance Updates, 2004 - Elsevier
The control of Leishmania infections relies primarily on chemotherapy. The arsenal of drugs
available for treating Leishmania infections is limited and includes pentavalent antimonials …
available for treating Leishmania infections is limited and includes pentavalent antimonials …
Drug resistance in leishmaniasis
J Chakravarty, S Sundar - Journal of global infectious diseases, 2010 - journals.lww.com
The treatment options of leishmaniasis are limited and far from satisfactory. For more than 60
years, treatment of leishmaniasis has centered around pentavalent antimonials (Sb v) …
years, treatment of leishmaniasis has centered around pentavalent antimonials (Sb v) …
Natural product based leads to fight against leishmaniasis
The growing incidence of parasitic resistance against generic pentavalent antimonials,
specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania …
specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania …
Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani
S Wyllie, ML Cunningham, AH Fairlamb - Journal of Biological Chemistry, 2004 - ASBMB
Despite extensive use of antimonial compounds in the treatment of leishmaniasis, their
mode of action remains uncertain. Here we show that trivalent antimony (Sb III) interferes …
mode of action remains uncertain. Here we show that trivalent antimony (Sb III) interferes …
Reactive Oxygen Species Production and Mitochondrial Dysfunction Contribute to Quercetin Induced Death in Leishmania amazonensis
F Fonseca-Silva, JDF Inacio, MM Canto-Cavalheiro… - PloS one, 2011 - journals.plos.org
Background Leishmaniasis, a parasitic disease caused by protozoa of the genus
Leishmania, affects more than 12 million people worldwide. Quercetin has generated …
Leishmania, affects more than 12 million people worldwide. Quercetin has generated …