An efficient and robust ABC approach to infer the rate and strength of adaptation

J Murga-Moreno, S Casillas, A Barbadilla… - G3: Genes …, 2024 - academic.oup.com
Inferring the effects of positive selection on genomes remains a critical step in characterizing
the ultimate and proximate causes of adaptation across species, and quantifying positive …

Positive selection analyses identify a single WWE domain residue that shapes ZAP into a more potent restriction factor against alphaviruses

S Huang, J Girdner, LAP Nguyen, C Sandoval… - Plos …, 2024 - journals.plos.org
The host interferon pathway upregulates intrinsic restriction factors in response to viral
infection. Many of them block a diverse range of viruses, suggesting that their antiviral …

[HTML][HTML] Rapid evolution of genes with anti-cancer functions during the origins of large bodies and cancer resistance in elephants

J Bowman, VJ Lynch - bioRxiv, 2024 - ncbi.nlm.nih.gov
Elephants have emerged as a model system to study the evolution of body size and cancer
resistance because, despite their immense size, they have a very low prevalence of cancer …

[HTML][HTML] Positive selection analyses identify a single WWE domain residue that shapes ZAP into a super restriction factor

S Huang, J Girdner, LAP Nguyen, D Enard, MMH Li - bioRxiv, 2023 - ncbi.nlm.nih.gov
The host interferon pathway upregulates intrinsic restriction factors in response to viral
infection. Many of them block a diverse range of viruses, suggesting that their antiviral …