The adverse outcomes on the offspring from maternal diabetes in pregnancy are
substantially documented. In this paper, we report main knowledge on impacts of maternal …

BACKGROUND: Animal experimentation has a long tradition in diabetes research and has
provided invaluable benefits with regard to insulin discovery and treatment assessment …

Background Type 1 diabetes mellitus is a chronic autoimmune disease caused by the
pathogenic action of T lymphocytes on insulin-producing beta cells. Previous clinical studies …

Abstract Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing
pancreatic β-cells are destroyed. Intestinal helminths can cause asymptomatic chronic and …

Type 1 diabetes in humans has as one of its complications inadequate bone formation,
resulting in osteopenia and delayed fracture healing. To investigate the mechanisms by …

Histological and molecular analysis of fracture healing in normal and diabetic animals
showed significantly enhanced removal of cartilage in diabetic animals. Increased cartilage …

Insulin-dependent diabetes mellitus (IDDM) is associated with increased risk of osteopenia/
osteoporosis in humans. The mechanisms accounting for diabetic bone loss remain unclear …

The insulin receptor substrate-2 (Irs2) branch of the insulin/IGF signaling system coordinates
peripheral insulin action and pancreatic β cell function, so mice lacking Irs2 display …

Pancreatic beta-cell loss through apoptosis represents a key factor in the pathogenesis of
diabetes; however, no effective approaches to block this process and preserve endogenous …

Pancreatic islet cell death is the cause of deficient insulin production in diabetes mellitus.
Approaches towards prevention of cell death are of prophylactic importance in control and …