In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …

The 826 G protein-coupled receptors (GPCRs) in the human proteome regulate key
physiological processes and thus have long been attractive drug targets. With the crystal …

A major goal in structural biology is to unravel how molecular machines function in detail. To
that end, solution-state NMR spectroscopy is ideally suited as it is able to study biological …

Membrane proteins are still heavily under-represented in the protein data bank (PDB),
owing to multiple bottlenecks. The typical low abundance of membrane proteins in their …

A third of the genes in prokaryotic and eukaryotic genomes encode membrane proteins that
are either essential for signal transduction and solute transport or function as scaffold …

GPCRs regulate all aspects of human physiology, and biophysical studies have deepened
our understanding of GPCR conformational regulation by different ligands. Yet there is no …

Membrane proteins mediate flow of molecules, signals, and energy between cells and
intracellular compartments. Understanding membrane protein function requires a detailed …

Compared to soluble protein counterparts, the understanding of membrane protein stability,
solvent interactions, and function are not as well understood. Recent advancements in …

Highly deuterated protein samples expand the biophysics and biological tool kit by
providing, among other qualities, contrast matching in neutron diffraction experiments and …

Tryptophan indole 15N–1H signals are well separated in nuclear magnetic resonance
(NMR) spectra of proteins. Assignment of the indole 15N–1H signals therefore enables one …