Stem cells and their local microenvironment, or niche, communicate through mechanical
cues to regulate cell fate and cell behaviour and to guide developmental processes. During …

A growing body of evidence suggests that mechanical signals emanating from the cell's
microenvironment are fundamental regulators of cell behaviour. Moreover, at the …

Neural tube closure has been studied for many decades, across a range of vertebrates, as a
paradigm of embryonic morphogenesis. Neurulation is of particular interest in view of the …

The vast opportunities for biomaterials design and functionality enabled by mimicking nature
continue to stretch the limits of imagination. As both biological understanding and …

Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains
proliferation, opposes cell death and regulates differentiation. Through integrins, cells …

The nucleus is linked mechanically to the extracellular matrix via multiple polymers that
transmit forces to the nuclear envelope and into the nuclear interior. Here, we review some …

All cells sense and integrate mechanical and biochemical cues from their environment to
orchestrate organismal development and maintain tissue homeostasis …

Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but
with the same chemical composition, size, and surface properties are assembled using a …

Mechanical signals are increasingly recognized as overarching regulators of cell behaviour,
controlling stemness, organoid biology, tissue development and regeneration. Moreover …

The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …