The role of histone modifications: from neurodevelopment to neurodiseases
J Park, K Lee, K Kim, SJ Yi - Signal transduction and targeted therapy, 2022 - nature.com
Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …
Regulation of adult neurogenesis in mammalian brain
Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …
The impact of neuroimmune alterations in autism spectrum disorder
C Gottfried, V Bambini-Junior, F Francis… - Frontiers in …, 2015 - frontiersin.org
Autism spectrum disorder (ASD) involves a complex interplay of both genetic and
environmental risk factors, with immune alterations and synaptic connection deficiency in …
environmental risk factors, with immune alterations and synaptic connection deficiency in …
Transdifferentiation: a new promise for neurodegenerative diseases
C Mollinari, J Zhao, L Lupacchini, E Garaci… - Cell Death & …, 2018 - nature.com
Neurodegenerative diseases are characterized by a gradual loss of cognitive and physical
functions. Medications for these disorders are limited and treat the symptoms only. There are …
functions. Medications for these disorders are limited and treat the symptoms only. There are …
MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1
C Zhang, W Ye, M Zhao, L Long, D Xia… - International Journal of …, 2023 - nature.com
Mesenchymal stem cell (MSC)-based therapy has emerged as a promising treatment for
spinal cord injury (SCI), but improving the neurogenic potential of MSCs remains a …
spinal cord injury (SCI), but improving the neurogenic potential of MSCs remains a …
Invited review: epigenetics in neurodevelopment
RD Salinas, DR Connolly… - … and applied neurobiology, 2020 - Wiley Online Library
Neural development requires the orchestration of dynamic changes in gene expression to
regulate cell fate decisions. This regulation is heavily influenced by epigenetics, heritable …
regulate cell fate decisions. This regulation is heavily influenced by epigenetics, heritable …
Autism-related transcription factors underlying the sex-specific effects of prenatal bisphenol a exposure on transcriptome-interactome profiles in the offspring prefrontal …
S Kanlayaprasit, S Thongkorn, P Panjabud… - International Journal of …, 2021 - mdpi.com
Bisphenol A (BPA) is an environmental risk factor for autism spectrum disorder (ASD). BPA
exposure dysregulates ASD-related genes in the hippocampus and neurological functions …
exposure dysregulates ASD-related genes in the hippocampus and neurological functions …
Nucleus accumbens deep brain stimulation for a patient with self-injurious behavior and autism spectrum disorder: functional and structural changes of the brain …
The aim of this report was to investigate the clinical outcome of deep brain stimulation (DBS)
for autism spectrum disorder (ASD) and the functional and structural changes in the brain …
for autism spectrum disorder (ASD) and the functional and structural changes in the brain …
Expanding the neurodevelopmental phenotypes of individuals with de novo KMT2A variants
AJS Chan, C Cytrynbaum, N Hoang… - NPJ Genomic …, 2019 - nature.com
De novo loss-of-function (LoF) variants in the KMT2A gene are associated with
Wiedemann− Steiner Syndrome (WSS). Recently, de novo KMT2A variants have been …
Wiedemann− Steiner Syndrome (WSS). Recently, de novo KMT2A variants have been …
Direct cell-fate conversion of somatic cells: toward regenerative medicine and industries
K Horisawa, A Suzuki - Proceedings of the Japan Academy, Series B, 2020 - jstage.jst.go.jp
Cells of multicellular organisms have diverse characteristics despite having the same
genetic identity. The distinctive phenotype of each cell is determined by molecular …
genetic identity. The distinctive phenotype of each cell is determined by molecular …