The role of histone modifications: from neurodevelopment to neurodiseases

J Park, K Lee, K Kim, SJ Yi - Signal transduction and targeted therapy, 2022 - nature.com
Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Regulation of adult neurogenesis in mammalian brain

MV Niklison-Chirou, M Agostini, I Amelio… - International Journal of …, 2020 - mdpi.com
Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …

The impact of neuroimmune alterations in autism spectrum disorder

C Gottfried, V Bambini-Junior, F Francis… - Frontiers in …, 2015 - frontiersin.org
Autism spectrum disorder (ASD) involves a complex interplay of both genetic and
environmental risk factors, with immune alterations and synaptic connection deficiency in …

Transdifferentiation: a new promise for neurodegenerative diseases

C Mollinari, J Zhao, L Lupacchini, E Garaci… - Cell Death & …, 2018 - nature.com
Neurodegenerative diseases are characterized by a gradual loss of cognitive and physical
functions. Medications for these disorders are limited and treat the symptoms only. There are …

MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1

C Zhang, W Ye, M Zhao, L Long, D Xia… - International Journal of …, 2023 - nature.com
Mesenchymal stem cell (MSC)-based therapy has emerged as a promising treatment for
spinal cord injury (SCI), but improving the neurogenic potential of MSCs remains a …

Invited review: epigenetics in neurodevelopment

RD Salinas, DR Connolly… - … and applied neurobiology, 2020 - Wiley Online Library
Neural development requires the orchestration of dynamic changes in gene expression to
regulate cell fate decisions. This regulation is heavily influenced by epigenetics, heritable …

Autism-related transcription factors underlying the sex-specific effects of prenatal bisphenol a exposure on transcriptome-interactome profiles in the offspring prefrontal …

S Kanlayaprasit, S Thongkorn, P Panjabud… - International Journal of …, 2021 - mdpi.com
Bisphenol A (BPA) is an environmental risk factor for autism spectrum disorder (ASD). BPA
exposure dysregulates ASD-related genes in the hippocampus and neurological functions …

Nucleus accumbens deep brain stimulation for a patient with self-injurious behavior and autism spectrum disorder: functional and structural changes of the brain …

HR Park, IH Kim, H Kang, DS Lee, BN Kim, DG Kim… - Acta …, 2017 - Springer
The aim of this report was to investigate the clinical outcome of deep brain stimulation (DBS)
for autism spectrum disorder (ASD) and the functional and structural changes in the brain …

Expanding the neurodevelopmental phenotypes of individuals with de novo KMT2A variants

AJS Chan, C Cytrynbaum, N Hoang… - NPJ Genomic …, 2019 - nature.com
De novo loss-of-function (LoF) variants in the KMT2A gene are associated with
Wiedemann− Steiner Syndrome (WSS). Recently, de novo KMT2A variants have been …

Direct cell-fate conversion of somatic cells: toward regenerative medicine and industries

K Horisawa, A Suzuki - Proceedings of the Japan Academy, Series B, 2020 - jstage.jst.go.jp
Cells of multicellular organisms have diverse characteristics despite having the same
genetic identity. The distinctive phenotype of each cell is determined by molecular …