Pseudomonas aeruginosa is a major cause of life-threatening acute infections and life-long
lasting chronic infections. The characteristic biofilm mode of life in P. aeruginosa chronic …

Background The aim of this study was to investigate an in vitro dynamic bioreactor model by
evaluating the antimicrobial effect of clinically relevant amoxicillin doses on polymicrobial …

Pseudomonas aeruginosa remains a challenge in chronic respiratory infections in cystic
fibrosis (CF). Ceftolozane-tazobactam has not yet been evaluated against multidrug …

Augmented renal clearance (ARC, creatinine clearance> 130 mL/minute) makes difficult
achievement of effective concentrations of renally cleared antibiotics in critically ill patients …

Acute exacerbations of chronic respiratory infections in patients with cystic fibrosis are highly
challenging due to hypermutable Pseudomonas aeruginosa, biofilm formation and …

Abstract Objective Hypermutable Pseudomonas aeruginosa strains are highly prevalent in
chronic lung infections of patients with cystic fibrosis (CF). Acute exacerbations of these …

The emergence of antibiotic resistance has severely impaired the treatment of chronic
respiratory infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa. Since …

Introduction Device-related infections are difficult to treat due to biofilms. In this setting,
optimizing antibiotic efficacy is difficult as most pharmacokinetic/pharmacdynamic (PK/PD) …

Biofilms are organized bacterial communities embedded in an extracellular polymeric matrix
attached to living or abiotic surfaces or forming aggregates. This mode of growth is …

Pseudomonas aeruginosa (Pa) ist ein Gram-negatives Bakterium, welches vor allem
nosokomiale Infektionen wie Pneumonie oder Sepsis verursacht. Ebenso bei Patienten mit …