Roles of mRNA poly (A) tails in regulation of eukaryotic gene expression
LA Passmore, J Coller - Nature Reviews Molecular Cell Biology, 2022 - nature.com
In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …
Intracellular mRNA transport and localized translation
Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …
precise temporal and spatial control of gene expression. High-resolution imaging …
Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability
Summary N6-methyladenosine (m6A), a widespread destabilizing mark on mRNA, is non-
uniformly distributed across the transcriptome, yet the basis for its selective deposition is …
uniformly distributed across the transcriptome, yet the basis for its selective deposition is …
Thoughts on how to think (and talk) about RNA structure
Recent events have pushed RNA research into the spotlight. Continued discoveries of RNA
with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as …
with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as …
Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers
Cellular RNAs are naturally decorated with a variety of chemical modifications. The
structural diversity of the modified nucleosides provides regulatory potential to sort groups of …
structural diversity of the modified nucleosides provides regulatory potential to sort groups of …
Properties of stress granule and P-body proteomes
Stress granules and P-bodies are cytosolic biomolecular condensates that dynamically form
by the phase separation of RNAs and proteins. They participate in translational control and …
by the phase separation of RNAs and proteins. They participate in translational control and …
Spontaneous driving forces give rise to protein− RNA condensates with coexisting phases and complex material properties
S Boeynaems, AS Holehouse… - Proceedings of the …, 2019 - National Acad Sciences
Phase separation of multivalent protein and RNA molecules underlies the biogenesis of
biomolecular condensates such as membraneless organelles. In vivo, these condensates …
biomolecular condensates such as membraneless organelles. In vivo, these condensates …
mRNA recognition and packaging by the human transcription–export complex
B Pacheco-Fiallos, MK Vorländer, D Riabov-Bassat… - Nature, 2023 - nature.com
Newly made mRNAs are processed and packaged into mature ribonucleoprotein complexes
(mRNPs) and are recognized by the essential transcription–export complex (TREX) for …
(mRNPs) and are recognized by the essential transcription–export complex (TREX) for …
[HTML][HTML] RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation
J Guillén-Boixet, A Kopach, AS Holehouse, S Wittmann… - Cell, 2020 - cell.com
Stressed cells shut down translation, release mRNA molecules from polysomes, and form
stress granules (SGs) via a network of interactions that involve G3BP. Here we focus on the …
stress granules (SGs) via a network of interactions that involve G3BP. Here we focus on the …
Illuminating RNA biology through imaging
RNA processing plays a central role in accurately transmitting genetic information into
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …