Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Autophagy, originally found in liver experiments, is a cellular process that degrades
damaged organelle or protein aggregation. This process frees cells from various stress …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Liquid-liquid phase separation (LLPS) compartmentalizes transcriptional condensates for
gene expression, but little is known about how this process is controlled. Here, we showed …

Age is one of the key risk factors to develop malignant diseases leading to a high incidence
of hepatic tumors in the elderly population. The only curative treatment for hepatic tumors is …

Nonalcoholic fatty liver disease (NAFLD) is becoming an increasingly serious disease
worldwide. Unfortunately, no specific drug has been approved to treat NAFLD. Accumulating …

Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of
inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules …

Hepatic glucose production (HGP) is crucial for the maintenance of normal glucose
homeostasis. Although hepatic insulin resistance contributes to excessive glucose …

Excessive bone resorption induced by increased osteoclast activity in postmenopausal
women often causes osteoporosis. Although the pharmacological treatment of osteoporosis …

Simple Summary Acute myeloid leukemia is a rare blood cancer that develops from the
clonal expansion of malignant myeloid precursor cells located in the bone marrow. Despite …