Adipogenesis: a complex interplay of multiple molecular determinants and pathways

MA Ambele, P Dhanraj, R Giles, MS Pepper - International journal of …, 2020 - mdpi.com
The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

Transcriptional and epigenomic regulation of adipogenesis

JE Lee, H Schmidt, B Lai, K Ge - Molecular and cellular biology, 2019 - Taylor & Francis
Understanding adipogenesis, the process of adipocyte development, may provide new ways
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

[HTML][HTML] A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis

S Ahmadi, S Wang, R Nagpal, B Wang, S Jain… - JCI insight, 2020 - ncbi.nlm.nih.gov
Inflammation is a major risk factor of morbidity and mortality in older adults. Although its
precise etiology is unknown, low-grade inflammation in older adults is commonly associated …

Oncohistone mutations enhance chromatin remodeling and alter cell fates

JD Bagert, MM Mitchener, AL Patriotis, BE Dul… - Nature chemical …, 2021 - nature.com
Whole-genome sequencing data mining efforts have revealed numerous histone mutations
in a wide range of cancer types. These occur in all four core histones in both the tail and …

Understanding histone H3 lysine 36 methylation and its deregulation in disease

J Li, JH Ahn, GG Wang - Cellular and Molecular Life Sciences, 2019 - Springer
Methylation of histone H3 lysine 36 (H3K36) plays crucial roles in the partitioning of
chromatin to distinctive domains and the regulation of a wide range of biological processes …

Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes

S Yano, T Ishiuchi, S Abe, SH Namekawa… - Nature …, 2022 - nature.com
Establishment of the DNA methylation landscape of mammalian oocytes, mediated by the
DNMT3A-DNMT3L complex, is crucial for reproduction and development. In mouse oocytes …

Global regulation of the histone mark H3K36me2 underlies epithelial plasticity and metastatic progression

S Yuan, R Natesan, FJ Sanchez-Rivera, J Li… - Cancer discovery, 2020 - AACR
Epithelial plasticity, reversible modulation of a cell's epithelial and mesenchymal features, is
associated with tumor metastasis and chemoresistance, leading causes of cancer mortality …

The PPARα and PPARγ epigenetic landscape in cancer and immune and metabolic disorders

J Porcuna, J Mínguez-Martínez, M Ricote - International journal of …, 2021 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are ligand-modulated nuclear
receptors that play pivotal roles in nutrient sensing, metabolism, and lipid-related processes …

H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis

R Shao, J Suo, Z Zhang, M Kong, Y Ma… - Cell Death & …, 2024 - nature.com
Osteoarthritis (OA) is one of the most common joint diseases, there are no effective disease-
modifying drugs, and the pathological mechanisms of OA need further investigation. Here …