When platelet numbers are low or when their function is disabled, the risk of bleeding is
high, which on the one hand indicates that in normal life vascular damage is a rather …

Platelets are small anucleated fragments derived from a megakaryocyte precursor. Platelets
play a key role in many physiological functions especially in hemostasis and wound healing …

Thrombosis and inflammation are intricately linked in several major clinical disorders,
including disseminated intravascular coagulation and acute ischemic events. The damage …

Guanylyl cyclases are a family of enzymes that catalyze the conversion of GTP to cGMP. The
family comprises both membrane-bound and soluble isoforms that are expressed in nearly …

Platelets are specialized blood cells that play central roles in physiologic and pathologic
processes of hemostasis, inflammation, tumor metastasis, wound healing, and host defense …

▪ Abstract Ena/VASP proteins are a conserved family of actin regulatory proteins made up of
EVH1, EVH2 domains, and a proline-rich central region. They have been implicated in actin …

Endothelial prostacyclin and nitric oxide potently inhibit platelet functions. Prostacyclin and
nitric oxide actions are mediated by platelet adenylyl and guanylyl cyclases, which …

We report the first RNAi-induced phenotypes in mammalian cultured cells using RNA
interference mediated by duplexes of 21-nt RNAs. The 21 gene products studied have …

Nitric oxide (NO) is a structurally simple, highly versatile molecule that was originally
discovered over 30 years ago as an endothelium-derived relaxing factor. In addition to its …

Integrin adhesion receptors link the extracellular matrix (ECM) 1 to the actin cytoskeleton
and transmit biochemical signals and mechanical force across the plasma membrane. This …