The effects of general anesthetics on mitochondrial structure and function in the developing brain
K Hogarth, D Tarazi, JT Maynes - Frontiers in Neurology, 2023 - frontiersin.org
The use of general anesthetics in modern clinical practice is commonly regarded as safe for
healthy individuals, but exposures at the extreme ends of the age spectrum have been …
healthy individuals, but exposures at the extreme ends of the age spectrum have been …
Anesthetic neurotoxicity: Apoptosis and autophagic cell death mediated by calcium dysregulation
M Yang, H Wei - Neurotoxicology and teratology, 2017 - Elsevier
A number of findings suggested that general anesthetics induced neural cell death by
apoptosis in various animal models. Although clinical evidence regarding the correlation …
apoptosis in various animal models. Although clinical evidence regarding the correlation …
Genistein attenuates isoflurane-induced neuroinflammation by inhibiting TLR4-mediated microglial-polarization in vivo and in vitro
T Jiang, S Xu, Y Shen, Y Xu, Y Li - Journal of Inflammation …, 2021 - Taylor & Francis
Background Isoflurane, a widely used anesthetic in surgery, has been found to induce
neurotoxicity. In parallel, genistein is thought to attenuate isoflurane-induced neurotoxicity …
neurotoxicity. In parallel, genistein is thought to attenuate isoflurane-induced neurotoxicity …
Exposure to general anesthesia and risk of dementia: a nationwide population-based cohort study
Background: There is a growing concern that general anesthesia could increase the risk of
dementia. However, the relationship between anesthesia and subsequent dementia is still …
dementia. However, the relationship between anesthesia and subsequent dementia is still …
Nitric oxide donor prevents neonatal isoflurane induced impairments in synaptic plasticity and memory
ML Schaefer, M Wang, PJ Perez, WC Peralta… - …, 2019 - pmc.ncbi.nlm.nih.gov
Background: In humans, multiple early exposures to procedures requiring anesthesia is a
significant risk factor for development of learning disabilities and disorders of attention and …
significant risk factor for development of learning disabilities and disorders of attention and …
Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols
J Horacek, R Janda, N Görnerova, L Jajcay… - Neuroscience …, 2023 - Elsevier
Ketamine exerts anti-inflammatory, neuroprotective and neuroplastic activity, therefore it may
counteract the neurotoxic processes underlying postoperative delirium. However, the …
counteract the neurotoxic processes underlying postoperative delirium. However, the …
Neurotoxicity of anesthesia in children: prevention and treatment
AE Vinson, CS Houck - Current treatment options in neurology, 2018 - Springer
Purpose of review The purpose of this review is to summarize the current evidence
regarding the impact of the exposure to anesthetic and sedative agents on …
regarding the impact of the exposure to anesthetic and sedative agents on …
Neurogenesis and developmental anesthetic neurotoxicity
The mechanism by which anesthetics might act on the developing brain in order to cause
long term deficits remains incompletely understood. The hippocampus has been identified …
long term deficits remains incompletely understood. The hippocampus has been identified …
[HTML][HTML] An update on preclinical research in anesthetic-induced developmental neurotoxicity in nonhuman primate and rodent models
The 2022 Pediatric Anesthesia and NeuroDevelopment Assessment (PANDA) Meeting
included an update on preclinical research in the field of anesthetic-induced developmental …
included an update on preclinical research in the field of anesthetic-induced developmental …
Selective induction of IL-1β after a brief isoflurane anesthetic in children undergoing MRI examination
EE Whitaker, FL Christofi, KM Quinn, BZ Wiemann… - Journal of …, 2017 - Springer
Purpose To determine if isoflurane anesthesia without surgery causes systemic
inflammation in children. Inflammation is targeted as responsible for the development of …
inflammation in children. Inflammation is targeted as responsible for the development of …