Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets

Z Zhong, CT Vong, F Chen, H Tan… - Medicinal Research …, 2022 - Wiley Online Library
Immunotherapy sheds new light to cancer treatment and is satisfied by cancer patients.
However, immunotoxicity, single‐source antibodies, and single‐targeting stratege are …

Prime-boost vaccine strategy against viral infections: Mechanisms and benefits

K Kardani, A Bolhassani, S Shahbazi - Vaccine, 2016 - Elsevier
The essential goal of vaccination is to generate potent and long-term protection against
diseases. Among different vaccine modalities, prime-boost vaccine strategies could …

Immunizing compositions comprising nucleic acids encoding the HIV-1 matrix protein myristate binding site

NM Karp - US Patent 7,718,180, 2010 - Google Patents
The present invention relates to an immunogenic composi tion. More particularly, the
present invention is a composition directed to eliciting an immune response to at least one …

Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity

ML Gillison - Seminars in oncology, 2004 - Elsevier
There is currently sufficient evidence to conclude that human papillomavirus (HPV) plays a
role in the pathogenesis of a distinct subset of head and neck squamous cell cancers …

Heat-shock proteins as activators of the innate immune system

RPA Wallin, A Lundqvist, SH Moré, A von Bonin… - Trends in …, 2002 - cell.com
Peptides bound or linked to heat-shock proteins (HSPs) of microbial or mammalian origin
have been shown to elicit potent antigen-specific immunity. Some members of the HSP …

Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine

X Hong, L Wei, F Wu, Z Wu, L Chen, Z Liu… - Drug design …, 2013 - Taylor & Francis
Microneedles were first conceptualized for drug delivery many decades ago, overcoming the
shortages and preserving the advantages of hypodermic needle and conventional …

Antigen‐specific immunotherapy of cervical and ovarian cancer

CF Hung, TC Wu, A Monie, R Roden - Immunological reviews, 2008 - Wiley Online Library
We contrast the efforts to treat ovarian cancer and cervical cancer through vaccination
because of their different pathobiology. A plethora of approaches have been developed for …

Spinning molecular immunology into successful immunotherapy

DM Pardoll - Nature Reviews Immunology, 2002 - nature.com
Until recently, immunotherapies have been of limited success, particularly against cancer.
However, recent insights into the cells, molecules and signalling pathways that regulate …

Development of DNA vaccine targeting E6 and E7 proteins of human papillomavirus 16 (HPV16) and HPV18 for immunotherapy in combination with recombinant …

S Peng, L Ferrall, S Gaillard, C Wang, WY Chi… - MBio, 2021 - Am Soc Microbiol
Immunotherapy for cervical cancer should target high-risk human papillomavirus types 16
and 18, which cause 50% and 20% of cervical cancers, respectively. Here, we describe the …

[HTML][HTML] Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen

WF Cheng, CF Hung, CY Chai, KF Hsu… - The Journal of …, 2001 - Am Soc Clin Investig
Antigen-specific cancer immunotherapy and antiangiogenesis have emerged as two
attractive strategies for cancer treatment. An innovative approach that combines both …