Macrophages are key immune cells that respond to infections, and modulate
pathophysiological conditions such as wound healing. By possessing phagocytic activities …

Venous leg ulcers (VLUs) are one of the most common ulcers of the lower extremity. VLU
affects many individuals worldwide, could pose a significant socioeconomic burden to the …

Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various
ischemic and inflammatory diseases. A rich variety of pro-and antiangiogenic molecules …

Macrophages are mononuclear phagocytes established during embryogenesis and derived
from the yolk sac or the fetal liver but also recruited from the blood and bone marrow under …

The present paper presents a hypothesis aimed at explaining why venous leg ulcers,
pressure ulcers, and diabetic foot ulcers develop into a chronic state. We propose that the …

Zinc is an essential trace element in the human body and its importance in health and
disease is appreciated. It serves as a cofactor in numerous transcription factors and enzyme …

Although it is known that systemic diseases such as diabetes result in impaired wound
healing, the mechanism for this impairment is not understood. Because fibroblasts are …

Multidrug-resistant, Gram-negative infection is a major global determinant of morbidity,
mortality and cost of care. The advent of nanomedicine has enabled tailored engineering of …

Objective: In the past 20 years, research and clinical trials on the healing process of chronic
wounds have highlighted the key role of the family of enzymes called matrix …

Cutaneous wound healing is a complex mechanism with multiple processes orchestrating
harmoniously for structural and functional restoration of the damaged tissue. Chronic non …