Aligning and comparing genomic sequences enables the identification of conserved
sequence signatures and can enrich for coding and noncoding functional regions. In …

Comparative genomics has revealed a class of non-protein-coding genomic sequences that
display an extraordinary degree of conservation between two or more organisms, regularly …

Lampreys are representatives of an ancient vertebrate lineage that diverged from our own∼
500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) …

The Sox2 gene is a key regulator of pluripotency embedded within an intron of a long
noncoding RNA (ncRNA), termed Sox2 overlapping transcript (Sox2ot), which is transcribed …

Ultraconserved elements were discovered two decades ago, arbitrarily defined as
sequences that are identical over a length≥ 200 bp in the human, mouse, and rat genomes …

The identification and characterization of the regulatory activity of genomic sequences is
crucial for understanding how the information contained in genomes is translated into …

Abstract UCNEbase (http://ccg. vital-it. ch/UCNEbase) is a free, web-accessible information
resource on the evolution and genomic organization of ultra-conserved non-coding …

Many important model organisms for biomedical and evolutionary research have sequenced
genomes, but occupy a phylogenetically isolated position, evolutionarily distant from other …

The sonic hedgehog (Shh) pathway plays indispensable roles in the morphogenesis of
mouse epithelial linings of the oral cavity and respiratory and digestive tubes. However, no …

The HLA-G (human leukocyte antigen-G) molecule plays a pivotal role in immune tolerance
by inhibiting different cell subsets involved in both innate and adaptive immunity. Besides its …