The gut microbiome as a modulator of healthy ageing
The gut microbiome is a contributory factor in ageing-related health loss and in several non-
communicable diseases in all age groups. Some age-linked and disease-linked …
communicable diseases in all age groups. Some age-linked and disease-linked …
Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
CA Akdis - Nature Reviews Immunology, 2021 - nature.com
There has been a steep increase in allergic and autoimmune diseases, reaching epidemic
proportions and now affecting more than one billion people worldwide. These diseases are …
proportions and now affecting more than one billion people worldwide. These diseases are …
Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma
Growing up on a farm is associated with an asthma-protective effect, but the mechanisms
underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural …
underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural …
Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children
As the incidence of immune-mediated diseases has increased rapidly in developed
societies, there is an unmet need for novel prophylactic practices to fight against these …
societies, there is an unmet need for novel prophylactic practices to fight against these …
Current understanding of the human microbiome
Our understanding of the link between the human microbiome and disease, including
obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding …
obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding …
Human immune diversity: from evolution to modernity
The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
The role of lung and gut microbiota in the pathology of asthma
Asthma is a common chronic respiratory disease affecting more than 300 million people
worldwide. Clinical features of asthma and its immunological and molecular etiology vary …
worldwide. Clinical features of asthma and its immunological and molecular etiology vary …
Gut microbiota and IBD: causation or correlation?
J Ni, GD Wu, L Albenberg, VT Tomov - Nature reviews Gastroenterology …, 2017 - nature.com
A general consensus exists that IBD is associated with compositional and metabolic
changes in the intestinal microbiota (dysbiosis). However, a direct causal relationship …
changes in the intestinal microbiota (dysbiosis). However, a direct causal relationship …
Dysbiosis of the gut and lung microbiome has a role in asthma
K Hufnagl, I Pali-Schöll, F Roth-Walter… - Seminars in …, 2020 - Springer
Worldwide 300 million children and adults are affected by asthma. The development of
asthma is influenced by environmental and other exogenous factors synergizing with …
asthma is influenced by environmental and other exogenous factors synergizing with …
After asthma: redefining airways diseases
Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …
costs. Substantial progress was made against key outcomes such as hospital admissions …