An overview of coumarin as a versatile and readily accessible scaffold with broad-ranging biological activities

F Annunziata, C Pinna, S Dallavalle… - International Journal of …, 2020 - mdpi.com
Privileged structures have been widely used as an effective template for the research and
discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and …

Styryl group, a friend or foe in medicinal chemistry

D Bhurta, SB Bharate - ChemMedChem, 2022 - Wiley Online Library
Abstract The styryl (Ph‐CH= CH‐R) group is widely represented in medicinally important
compounds, including drugs, clinical candidates, and molecular probes as it positively …

Evaluation of the effects of genistein in vitro as a chemopreventive agent for colorectal cancer—strategy to improve its efficiency when administered orally

JP Rendón, AI Cañas, E Correa, V Bedoya-Betancur… - Molecules, 2022 - mdpi.com
Colorectal Cancer (CRC) ranks third in terms of incidence and second in terms of mortality
and prevalence worldwide. In relation to chemotherapy treatment, the most used drug is 5 …

Theoretical study on the radical scavenging activity and mechanism of four kinds of Gnetin molecule

Y Shang, X Li, Z Li, J Zhou, L Qu, K Chen - Food Chemistry, 2022 - Elsevier
As an important subgroup of resveratrol oligomers, Gnetins received much attention due to
their antioxidants. The four Gnetin molecules are divided into two major categories …

Proapoptotic Effect and Molecular Docking Analysis of Curcumin–Resveratrol Hybrids in Colorectal Cancer Chemoprevention

G Moreno-Q, A Herrera-R, AF Yepes, TW Naranjo… - Molecules, 2022 - mdpi.com
Different hybrids based on curcumin and resveratrol were previously synthesized and
characterized by spectroscopic techniques. The most active molecules (3a, 3e, 3i, and 3k) …

Investigation of the cytotoxicity of bioinspired coumarin analogues towards human breast cancer cells

L Gkionis, E Kavetsou, A Kalospyros, D Manousakis… - Molecular Diversity, 2021 - Springer
Coumarins possess a wide array of therapeutic capabilities, but often with unclear
mechanism of action. We tested a small library of 18 coumarin derivatives against human …

Synthesis of furocoumarin–stilbene hybrids as potential multifunctional drugs against multiple biochemical targets associated with Alzheimer's disease

EN Agbo, S Gildenhuys, YS Choong, MJ Mphahlele… - Bioorganic …, 2020 - Elsevier
A series of furocoumarin-stilbene hybrids has been synthesized and evaluated in vitro for
inhibitory effect against acetylcholinesterase (AChE), butyrylcholinestarase (BChE), β …

New hybrids based on curcumin and resveratrol: synthesis, cytotoxicity and antiproliferative activity against colorectal cancer cells

C Hernández, G Moreno, A Herrera-R, W Cardona-G - Molecules, 2021 - mdpi.com
We synthesized twelve hybrids based on curcumin and resveratrol, and their structures were
elucidated by spectroscopic analysis. The chemopreventive potential of these compounds …

Synthesis and cytotoxic effects on pancreatic cancer cells of resveratrol analogs

B De Filippis, L De Lellis, R Florio… - Medicinal Chemistry …, 2019 - Springer
In this study, a series of resveratrol analogs was synthesized and the effects on the viability
of pancreatic cancer cell lines were evaluated. The new molecules were designed by …

[HTML][HTML] In-vitro chemopreventive potential of a chromone from bomarea setacea (ALSTROEMERIACEAE) against colorectal cancer

A Herrera-R, G Moreno, P Araque… - Iranian Journal of …, 2021 - ncbi.nlm.nih.gov
Chemoprevention with natural products may provide important alternatives in the search for
new drugs to treat cancer. Thus, the ethanol extract of Bomarea setacea and its secondary …