An overview of coumarin as a versatile and readily accessible scaffold with broad-ranging biological activities
F Annunziata, C Pinna, S Dallavalle… - International Journal of …, 2020 - mdpi.com
Privileged structures have been widely used as an effective template for the research and
discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and …
discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and …
Styryl group, a friend or foe in medicinal chemistry
D Bhurta, SB Bharate - ChemMedChem, 2022 - Wiley Online Library
Abstract The styryl (Ph‐CH= CH‐R) group is widely represented in medicinally important
compounds, including drugs, clinical candidates, and molecular probes as it positively …
compounds, including drugs, clinical candidates, and molecular probes as it positively …
Evaluation of the effects of genistein in vitro as a chemopreventive agent for colorectal cancer—strategy to improve its efficiency when administered orally
Colorectal Cancer (CRC) ranks third in terms of incidence and second in terms of mortality
and prevalence worldwide. In relation to chemotherapy treatment, the most used drug is 5 …
and prevalence worldwide. In relation to chemotherapy treatment, the most used drug is 5 …
Theoretical study on the radical scavenging activity and mechanism of four kinds of Gnetin molecule
Y Shang, X Li, Z Li, J Zhou, L Qu, K Chen - Food Chemistry, 2022 - Elsevier
As an important subgroup of resveratrol oligomers, Gnetins received much attention due to
their antioxidants. The four Gnetin molecules are divided into two major categories …
their antioxidants. The four Gnetin molecules are divided into two major categories …
Proapoptotic Effect and Molecular Docking Analysis of Curcumin–Resveratrol Hybrids in Colorectal Cancer Chemoprevention
G Moreno-Q, A Herrera-R, AF Yepes, TW Naranjo… - Molecules, 2022 - mdpi.com
Different hybrids based on curcumin and resveratrol were previously synthesized and
characterized by spectroscopic techniques. The most active molecules (3a, 3e, 3i, and 3k) …
characterized by spectroscopic techniques. The most active molecules (3a, 3e, 3i, and 3k) …
Investigation of the cytotoxicity of bioinspired coumarin analogues towards human breast cancer cells
L Gkionis, E Kavetsou, A Kalospyros, D Manousakis… - Molecular Diversity, 2021 - Springer
Coumarins possess a wide array of therapeutic capabilities, but often with unclear
mechanism of action. We tested a small library of 18 coumarin derivatives against human …
mechanism of action. We tested a small library of 18 coumarin derivatives against human …
Synthesis of furocoumarin–stilbene hybrids as potential multifunctional drugs against multiple biochemical targets associated with Alzheimer's disease
EN Agbo, S Gildenhuys, YS Choong, MJ Mphahlele… - Bioorganic …, 2020 - Elsevier
A series of furocoumarin-stilbene hybrids has been synthesized and evaluated in vitro for
inhibitory effect against acetylcholinesterase (AChE), butyrylcholinestarase (BChE), β …
inhibitory effect against acetylcholinesterase (AChE), butyrylcholinestarase (BChE), β …
New hybrids based on curcumin and resveratrol: synthesis, cytotoxicity and antiproliferative activity against colorectal cancer cells
C Hernández, G Moreno, A Herrera-R, W Cardona-G - Molecules, 2021 - mdpi.com
We synthesized twelve hybrids based on curcumin and resveratrol, and their structures were
elucidated by spectroscopic analysis. The chemopreventive potential of these compounds …
elucidated by spectroscopic analysis. The chemopreventive potential of these compounds …
Synthesis and cytotoxic effects on pancreatic cancer cells of resveratrol analogs
B De Filippis, L De Lellis, R Florio… - Medicinal Chemistry …, 2019 - Springer
In this study, a series of resveratrol analogs was synthesized and the effects on the viability
of pancreatic cancer cell lines were evaluated. The new molecules were designed by …
of pancreatic cancer cell lines were evaluated. The new molecules were designed by …
[HTML][HTML] In-vitro chemopreventive potential of a chromone from bomarea setacea (ALSTROEMERIACEAE) against colorectal cancer
A Herrera-R, G Moreno, P Araque… - Iranian Journal of …, 2021 - ncbi.nlm.nih.gov
Chemoprevention with natural products may provide important alternatives in the search for
new drugs to treat cancer. Thus, the ethanol extract of Bomarea setacea and its secondary …
new drugs to treat cancer. Thus, the ethanol extract of Bomarea setacea and its secondary …