Targeting the enzymes involved in arachidonic acid metabolism to improve radiotherapy
During radiotherapy, an inflammatory response might be induced by activating various
enzymes involved in membrane lipid metabolism. The eicosanoid pathway associated with …
enzymes involved in membrane lipid metabolism. The eicosanoid pathway associated with …
Polyamine homeostasis-based strategies for cancer: The role of combination regimens
QZ Li, ZW Zuo, ZR Zhou, Y Ji - European Journal of Pharmacology, 2021 - Elsevier
Spermine, spermidine and putrescine polyamines are naturally occurring ubiquitous
positively charged amines and are essential metabolites for biological functions in our life …
positively charged amines and are essential metabolites for biological functions in our life …
Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer
BM Kennedy, RE Harris - Inflammopharmacology, 2018 - Springer
We examined the expression of major inflammatory genes, cyclooxygenase-1 and 2 (COX1,
COX2) and arachidonate 5-lipoxygenase (ALOX5) in 1090 tumor samples of invasive breast …
COX2) and arachidonate 5-lipoxygenase (ALOX5) in 1090 tumor samples of invasive breast …
[HTML][HTML] Naproxen inhibits spontaneous lung adenocarcinoma formation in KrasG12V mice
Lung cancer is the leading cause of cancer related deaths worldwide. The present study
investigated the effects of naproxen (NSAID) on lung adenocarcinoma in spontaneous lung …
investigated the effects of naproxen (NSAID) on lung adenocarcinoma in spontaneous lung …
Pyrrolizines: design, synthesis, anticancer evaluation and investigation of the potential mechanism of action
A novel set of pyrrolizine-5-carboxamides has been synthesized and evaluated for their
anticancer potential against human breast MCF-7, lung carcinoma A549 and hepatoma …
anticancer potential against human breast MCF-7, lung carcinoma A549 and hepatoma …
Molecular modelling insights into a physiologically favourable approach to eicosanoid biosynthesis inhibition through novel thieno[2,3-b]pyridine derivatives
In this research, we exploited derivatives of thieno [2, 3-b] pyridine as dual inhibitors of the
key enzymes in eicosanoid biosynthesis, cyclooxygenase (COX, subtypes 1 and 2) and 5 …
key enzymes in eicosanoid biosynthesis, cyclooxygenase (COX, subtypes 1 and 2) and 5 …
WWOX inhibits the invasion of lung cancer cells by downregulating RUNX2
QW Zheng, YL Zhou, QJ You, F Shou, QF Pang… - Cancer Gene …, 2016 - nature.com
The WW domain-containing oxidoreductase (WWOX) is a tumor suppressor that is lost or
decreased in most human tumors. The role of WWOX in human lung carcinoma invasion is …
decreased in most human tumors. The role of WWOX in human lung carcinoma invasion is …
Discovery and development of a novel mPGES-1/5-LOX dual inhibitor LFA-9 for prevention and treatment of chronic inflammatory diseases
Background Non-steroidal anti-inflammatory drugs, cyclooxygenase (COX)-2 selective
inhibitors, have been explored for prevention and treatment of several inflammatory chronic …
inhibitors, have been explored for prevention and treatment of several inflammatory chronic …
[HTML][HTML] Systemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune …
Mitotic error-mediated chromosome instability (CIN) can lead to aneuploidy, chromothripsis,
DNA damage and/or whole chromosome gain/loss. CIN may prompt rapid accumulation of …
DNA damage and/or whole chromosome gain/loss. CIN may prompt rapid accumulation of …
Arsenic up-regulates PD-L1 and enhances lung tumorigenesis through activation of STAT3 in alveolar epithelial type 2 cells
W Xu, J Cui, AM Busayli, T Zhang, G Chen - Toxicology and Applied …, 2024 - Elsevier
Abstracts Arsenic is a carcinogen and chronic exposure to arsenic increases the risk of
many cancers, including lung cancer. However, the underlying mechanism is not clear …
many cancers, including lung cancer. However, the underlying mechanism is not clear …