Obesity increases risk of endometrial cancer through dysregulation of estrogen and insulin
signaling. The primary aim of this study was to evaluate the impact of metformin or lifestyle …

Obesity is recognized as the second highest risk factor for cancer. The pathogenic
mechanisms underlying tobacco-related cancers are well characterized and effective …

Introduction. Diabetic gastroparesis (DGP) is a common chronic complication of diabetes
characterized by decreased gastric motility, and an effective number of gastric smooth …

Cyclin-dependent kinase inhibitor 1B (Cdkn1b, p27) plays important regulatory roles in
many cellular processes. p27 is highly expressed in the mouse testis, but its roles and …

A non-genotoxic insecticide dichlorodiphenyltrichloroethane (DDT), can affect mRNA and
microRNA levels, however, its precise mechanism of action remains poorly understood …

Endometrial cancer is one of the major cancers in women throughout the world. If diagnosed
early, these cancers are treatable and the prognosis is usually good. However, one major …

The cell cycle regulation and tumor suppressor p27 encoded by CDKN1B plays a key role in
many cellular events. 1–3 p27 is a member of the Cip/Kip family of cyclin-dependent kinase …

The prevalence of obesity is a significant global health problem. Obesity results from excess
body fat accumulation due to altered energy balance between energy intake and energy …

Purpose: To study the mechanism by which adiponectin regulates the malignant biological
behavior of endometrial cancer cells. Methods: RL95-2 cells were cultured and re …

Endometrial cancer can generally be divided into two clinical subtypes, designated as type I
and type II disease, each with different risk factors, histology, genetics, treatment and …