Proteolysis targeting chimeras (PROTACs) technology has emerged as a novel therapeutic
paradigm in recent years. PROTACs are heterobifunctional molecules that degrade target …

The phosphoinositide 3-kinase (PI3K) signaling pathway is one of the most frequently
altered pathways in human cancer and has a critical role in driving tumor initiation and …

A sulfonamide is a functional group that is the basis of several sulfa drugs and thereby are
very much important scaffolds in medicinal as well as in synthetic organic chemistry …

Small molecule inhibitors of proteins represent important medicines and critical chemical
tools to investigate the biology of the target proteins. Advances in various-omics …

Mutations in cancer reprogram amino acid metabolism to drive tumor growth, but the
molecular mechanisms are not well understood. Using an unbiased proteomic screen, we …

Resistance to targeted therapies is an important clinical problem in HER2-positive (HER2+)
breast cancer.“Drug-tolerant persisters”(DTP), a subpopulation of cancer cells that survive …

PIK3CA, which encodes the p110α subunit of PI3K, is frequently mutated and oncogenic in
breast cancer. PI3Kα inhibitors are in clinical development and despite promising early …

SGK3 is a PX domain containing protein kinase activated at endosomes downstream of
class 1 and 3 PI3K family members by growth factors and oncogenic mutations. SGK3 plays …

Inducing post-translational protein knockdown is an important approach to probe biology
and validate drug targets. An efficient strategy to achieve this involves expression of a …

Activation of the PI3K pathway is central to a variety of physiological and pathological
processes. In these contexts, AKT is classically considered the de facto mediator of PI3K …