Genetics of human hypertension
A Agarwal, GH Williams, NDL Fisher - Trends in Endocrinology & …, 2005 - cell.com
Hypertension is a complex genetic disorder caused by interplay between several 'risk'genes
and environmental factors (genetic heritability∼ 30%). Most genetic studies of hypertension …
and environmental factors (genetic heritability∼ 30%). Most genetic studies of hypertension …
Genetic predisposition to salt-sensitivity: a systematic review
E Beeks, AGH Kessels, AA Kroon… - Journal of …, 2004 - journals.lww.com
We conducted a systematic review by searching the Medline literature from March 1993 to
June 2003. Each paper was scrutinized and data concerning study population, method of …
June 2003. Each paper was scrutinized and data concerning study population, method of …
Molecular basis of salt sensitivity in human hypertension: evaluation of renin-angiotensin-aldosterone system gene polymorphisms
E Poch, D González, V Giner, E Bragulat, A Coca… - …, 2001 - Am Heart Assoc
We analyzed the association between salt sensitivity in essential hypertension and 8 genetic
polymorphisms in 6 genes of the renin-angiotensin aldosterone system. Seventy-one …
polymorphisms in 6 genes of the renin-angiotensin aldosterone system. Seventy-one …
Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population
JA Staessen, JG Wang, E Brand… - Journal of …, 2001 - journals.lww.com
Background The genes encoding angiotensin converting enzyme (ACE, I/D), α-adducin
(ADD, Gly460Trp) and aldosterone synthase (AS,− 344C/T) share the potential of …
(ADD, Gly460Trp) and aldosterone synthase (AS,− 344C/T) share the potential of …
Racial and ethnic differences in microalbuminuria prevalence in a diabetes population: the pathways study
BA Young, WJ Katon, M Von Korff… - Journal of the …, 2005 - journals.lww.com
The objective of this study was to determine whether racial or ethnic differences in
prevalence of diabetic microalbuminuria were observed in a large primary care population …
prevalence of diabetic microalbuminuria were observed in a large primary care population …
Association of the C− 344T aldosterone synthase gene variant with essential hypertension: a meta-analysis
S Sookoian, TF Gianotti, CD González… - Journal of …, 2007 - journals.lww.com
Background The CYP11B2 gene (CYP11B2) encoding aldosterone synthase has been
associated with essential hypertension and some, but not all, studies have reported that the …
associated with essential hypertension and some, but not all, studies have reported that the …
Aldosterone synthase gene (CYP11B2) C-344T polymorphism, plasma aldosterone, renin activity and blood pressure in a multi-ethnic population
Background The aldosterone synthase gene (CYP1B2) locus is a candidate region involved
in the development of hypertension. Objective To study the relationship between the C-344T …
in the development of hypertension. Objective To study the relationship between the C-344T …
Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers
C Bengra, TE Mifflin, Y Khripin, P Manunta… - Clinical …, 2002 - academic.oup.com
Background: Human hypertension is a complex, multifactorial disease with a heritability of
more than 30–50%. A genetic screening test based on analysis of multiple single-nucleotide …
more than 30–50%. A genetic screening test based on analysis of multiple single-nucleotide …
Haplotype analysis of aldosterone synthase gene (CYP11B2) polymorphisms shows association with essential hypertension
Objective The CYP11B2 locus is an important candidate region in essential hypertension
(HT). We therefore investigated CYP11B2 polymorphisms T− 344C, T4986C and A6547G …
(HT). We therefore investigated CYP11B2 polymorphisms T− 344C, T4986C and A6547G …
Role of intracardiac renin-angiotensin-aldosterone system in extracellular matrix remodeling.
PJ Lijnen, VV Petrov - Methods and findings in experimental and …, 2003 - europepmc.org
Functional angiotensin II receptors have been documented in cardiac fibroblasts as well as
an intracardiac aldosterone system that responds to short-and long-term physiological …
an intracardiac aldosterone system that responds to short-and long-term physiological …