Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease

AK Vose, JF Welch, J Nair, EA Dale, EJ Fox… - Experimental …, 2022 - Elsevier
We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

Respiratory training and plasticity after cervical spinal cord injury

M Randelman, LV Zholudeva, S Vinit… - Frontiers in cellular …, 2021 - frontiersin.org
While spinal cord injuries (SCIs) result in a vast array of functional deficits, many of which
are life threatening, the majority of SCIs are anatomically incomplete. Spared neural …

Efficacy and time course of acute intermittent hypoxia effects in the upper extremities of people with cervical spinal cord injury

MS Sandhu, MA Perez, M Oudega, GS Mitchell… - Experimental …, 2021 - Elsevier
Spinal cord injuries (SCI) disrupt neural pathways between the brain and spinal cord,
causing impairment of motor function and loss of independent mobility. Spontaneous …

Hebbian priming of human motor learning

JR Bjørndal, MM Beck, L Jespersen… - Nature …, 2024 - nature.com
Motor learning relies on experience-dependent plasticity in relevant neural circuits. In four
experiments, we provide initial evidence and a double-blinded, sham-controlled replication …

Rostral-caudal effect of cervical magnetic stimulation on the diaphragm motor evoked potential after cervical spinal cord contusion in the rat

KZ Lee, LM Liou, S Vinit, MY Ren - Journal of Neurotrauma, 2022 - liebertpub.com
The present study was designed to investigate the rostral-caudal effect of spinal magnetic
stimulation on diaphragmatic motor-evoked potentials after cervical spinal cord injury. The …

Multiple N-of-1 trials to investigate hypoxia therapy in Parkinson's disease: study rationale and protocol

JM Janssen Daalen, MJ Meinders, F Giardina… - BMC neurology, 2022 - Springer
Background Parkinson's disease (PD) is a neurodegenerative disease, for which no disease-
modifying therapies exist. Preclinical and clinical evidence suggest that hypoxia-based …

The effect of acute intermittent hypoxia on human limb motoneurone output

HT Finn, O Bogdanovski, AL Hudson… - Experimental …, 2022 - Wiley Online Library
New Findings What is the central question of this study? Does a single session of repeated
bouts of acute intermittent hypoxic breathing enhance the motoneuronal output of the limb …

Prolonged acute intermittent hypoxia improves forelimb reach-to-grasp function in a rat model of chronic cervical spinal cord injury

BM Arnold, BM Toosi, S Caine, GS Mitchell… - Experimental …, 2021 - Elsevier
Repetitive acute intermittent hypoxia (AIH–brief, episodes of low inspired oxygen) elicits
spinal motor plasticity, resulting in sustained improvements of respiratory and non …

Respiratory plasticity following spinal cord injury: perspectives from mouse to man

KC Locke, ML Randelman, DJ Hoh… - Neural regeneration …, 2022 - journals.lww.com
The study of respiratory plasticity in animal models spans decades. At the bench,
researchers use an array of techniques aimed at harnessing the power of plasticity within …

Acute intermittent hypoxia enhances strength, and modulates spatial distribution of muscle activation in persons with chronic incomplete spinal cord injury

B Afsharipour, GEP Pearcey, WZ Rymer… - Experimental …, 2023 - Elsevier
Acute intermittent hypoxia (AIH) is an emerging technique for facilitating neural plasticity in
individuals with chronic incomplete spinal cord injury (iSCI). A single sequence of AIH …