Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease
We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …
strategy to improve respiratory and non-respiratory motor function in people with …
Respiratory training and plasticity after cervical spinal cord injury
M Randelman, LV Zholudeva, S Vinit… - Frontiers in cellular …, 2021 - frontiersin.org
While spinal cord injuries (SCIs) result in a vast array of functional deficits, many of which
are life threatening, the majority of SCIs are anatomically incomplete. Spared neural …
are life threatening, the majority of SCIs are anatomically incomplete. Spared neural …
Efficacy and time course of acute intermittent hypoxia effects in the upper extremities of people with cervical spinal cord injury
Spinal cord injuries (SCI) disrupt neural pathways between the brain and spinal cord,
causing impairment of motor function and loss of independent mobility. Spontaneous …
causing impairment of motor function and loss of independent mobility. Spontaneous …
Hebbian priming of human motor learning
JR Bjørndal, MM Beck, L Jespersen… - Nature …, 2024 - nature.com
Motor learning relies on experience-dependent plasticity in relevant neural circuits. In four
experiments, we provide initial evidence and a double-blinded, sham-controlled replication …
experiments, we provide initial evidence and a double-blinded, sham-controlled replication …
Rostral-caudal effect of cervical magnetic stimulation on the diaphragm motor evoked potential after cervical spinal cord contusion in the rat
The present study was designed to investigate the rostral-caudal effect of spinal magnetic
stimulation on diaphragmatic motor-evoked potentials after cervical spinal cord injury. The …
stimulation on diaphragmatic motor-evoked potentials after cervical spinal cord injury. The …
Multiple N-of-1 trials to investigate hypoxia therapy in Parkinson's disease: study rationale and protocol
Background Parkinson's disease (PD) is a neurodegenerative disease, for which no disease-
modifying therapies exist. Preclinical and clinical evidence suggest that hypoxia-based …
modifying therapies exist. Preclinical and clinical evidence suggest that hypoxia-based …
The effect of acute intermittent hypoxia on human limb motoneurone output
HT Finn, O Bogdanovski, AL Hudson… - Experimental …, 2022 - Wiley Online Library
New Findings What is the central question of this study? Does a single session of repeated
bouts of acute intermittent hypoxic breathing enhance the motoneuronal output of the limb …
bouts of acute intermittent hypoxic breathing enhance the motoneuronal output of the limb …
Prolonged acute intermittent hypoxia improves forelimb reach-to-grasp function in a rat model of chronic cervical spinal cord injury
BM Arnold, BM Toosi, S Caine, GS Mitchell… - Experimental …, 2021 - Elsevier
Repetitive acute intermittent hypoxia (AIH–brief, episodes of low inspired oxygen) elicits
spinal motor plasticity, resulting in sustained improvements of respiratory and non …
spinal motor plasticity, resulting in sustained improvements of respiratory and non …
Respiratory plasticity following spinal cord injury: perspectives from mouse to man
KC Locke, ML Randelman, DJ Hoh… - Neural regeneration …, 2022 - journals.lww.com
The study of respiratory plasticity in animal models spans decades. At the bench,
researchers use an array of techniques aimed at harnessing the power of plasticity within …
researchers use an array of techniques aimed at harnessing the power of plasticity within …
Acute intermittent hypoxia enhances strength, and modulates spatial distribution of muscle activation in persons with chronic incomplete spinal cord injury
Acute intermittent hypoxia (AIH) is an emerging technique for facilitating neural plasticity in
individuals with chronic incomplete spinal cord injury (iSCI). A single sequence of AIH …
individuals with chronic incomplete spinal cord injury (iSCI). A single sequence of AIH …