Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Extracellular matrix stiffening is a quintessential feature of cartilage aging, a leading cause
of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age …

Extracellular vesicles (EVs) are released from all cells in the body, forming an important
intercellular communication network that contributes to health and disease. The contents of …

Abstract Information storage and retrieval is essential for all life. In biology, information is
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …

The inherent limits of traditional diagnoses and therapies have driven the development and
application of emerging nanotechnologies for more effective and safer management of …

Given the rapidly aging population, aging-related diseases are becoming an excessive
burden on the global healthcare system. Metformin has been shown to be beneficial to many …

Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating
effects of young blood on aged tissues. However, the specific rejuvenating mechanisms …

Background α-Klotho is a geroprotective protein that can attenuate or alleviate deleterious
changes with ageing and disease. Declines in α-Klotho play a role in the pathophysiology of …

Aging is a degenerative process that leads to tissue dysfunction and death. Embryonic stem
cells (ESCs) have great therapeutic potential for age-related diseases due to their capacity …