Plasmodium asexual growth and sexual development in the haematopoietic niche of the host

K Venugopal, F Hentzschel, G Valkiūnas… - Nature Reviews …, 2020 - nature.com
Plasmodium spp. parasites are the causative agents of malaria in humans and animals, and
they are exceptionally diverse in their morphology and life cycles. They grow and develop in …

Sexual development in Plasmodium parasites: knowing when it's time to commit

GA Josling, M Llinás - Nature Reviews Microbiology, 2015 - nature.com
Malaria is a devastating infectious disease that is caused by blood-borne apicomplexan
parasites of the genus Plasmodium. These pathogens have a complex lifecycle, which …

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

AR Jensen, Y Adams, L Hviid - Immunological reviews, 2020 - Wiley Online Library
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Variant surface antigens of Plasmodium falciparum and their roles in severe malaria

M Wahlgren, S Goel, RR Akhouri - Nature Reviews Microbiology, 2017 - nature.com
Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …

Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria

SJ Gonzales, RA Reyes, AE Braddom… - Frontiers in …, 2020 - frontiersin.org
Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …

Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria

F Lennartz, Y Adams, A Bengtsson, RW Olsen… - Cell host & …, 2017 - cell.com
Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …

Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

F Saito, K Hirayasu, T Satoh, CW Wang, J Lusingu… - Nature, 2017 - nature.com
Malaria is among the most serious infectious diseases affecting humans, accounting for
approximately half a million deaths each year. Plasmodium falciparum causes most life …

A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens

J Tan, K Pieper, L Piccoli, A Abdi, M Foglierini… - Nature, 2016 - nature.com
Plasmodium falciparum antigens expressed on the surface of infected erythrocytes are
important targets of naturally acquired immunity against malaria, but their high number and …

Severe malaria: what's new on the pathogenesis front?

SC Wassmer, GER Grau - International journal for parasitology, 2017 - Elsevier
Plasmodium falciparum causes the most severe and fatal form of malaria in humans with
over half a million deaths each year. Cerebral malaria, a complex neurological syndrome of …

Sticking for a cause: the falciparum malaria parasites cytoadherence paradigm

WC Lee, B Russell, L Rénia - Frontiers in immunology, 2019 - frontiersin.org
After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …