Immunotherapy is currently under intensive investigation as a potential breakthrough
treatment option for glioblastoma. Given the anatomical and immunological complexities …

Hepatic expression of iron homeostasis genes and serum iron parameters predict the
success of immunosuppression withdrawal following clinical liver transplantation, a …

Neurodegeneration and neuroinflammation disorders are mainly the result of the deposition
of various proteins, such as α‐synuclein, amyloid‐β and prions, which lead to the initiation …

Mucolipidosis IV (MLIV) is an orphan neurodevelopmental disease that causes severe
neurologic dysfunction and loss of vision. Currently there is no therapy for MLIV. It is caused …

Background Iron is pivotal for life, but it is toxic if in excess. Iron overload mediated by
divalent metal transporter 1 (DMT1) in the central nervous system has participated in various …

In the central nervous system, viral infection can induce inflammation by up-regulating pro-
inflammatory mediators that contribute to enhanced infiltration of immune cells into the …

Background Astrocytes senescence has been demonstrated in the aging brain and
Alzheimer's disease (AD). Moreover, lower glucose metabolism has been confirmed in the …

The innate immune system is a prerequisite for biophylactic ability, but its dysregulation can
cause inflammatory and autoimmune diseases. To determine a safe method of controlling …

The functions of differentiated embryonic chondrocyte gene (DEC) 1, a basic helix-loop-helix
(bHLH) transcription factor, have been reported to be associated with the regulation of …

Transition metal ions, mainly iron, are involved in the generation of highly reactive hydroxyl
radicals, which are the most powerful inducers of oxidative damage to all biomolecules. The …