Mitochondrial proteases: multifaceted regulators of mitochondrial plasticity
Mitochondria are essential metabolic hubs that dynamically adapt to physiological demands.
More than 40 proteases residing in different compartments of mitochondria, termed …
More than 40 proteases residing in different compartments of mitochondria, termed …
Stress-induced FGF21 and GDF15 in obesity and obesity resistance
Fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15) are
established as stress-responsive cytokines that can modulate energy balance by increasing …
established as stress-responsive cytokines that can modulate energy balance by increasing …
[HTML][HTML] Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress
S Mohammed, EH Nicklas, N Thadathil… - Free Radical Biology …, 2021 - Elsevier
Mice deficient in the antioxidant enzyme Cu/Zn-superoxide dismutase (Sod1−/− or Sod1KO
mice) have increased oxidative stress, show accelerated aging and develop spontaneous …
mice) have increased oxidative stress, show accelerated aging and develop spontaneous …
Mitochondrial proteostasis in the context of cellular and organismal health and aging
As a central hub of cellular metabolism and signaling, the mitochondrion is a crucial
organelle whose dysfunction can cause disease and whose activity is intimately connected …
organelle whose dysfunction can cause disease and whose activity is intimately connected …
Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy
Mitochondrial ClpP is a serine protease located in the mitochondrial matrix. This protease
participates in mitochondrial protein quality control by degrading misfolded or damaged …
participates in mitochondrial protein quality control by degrading misfolded or damaged …
[HTML][HTML] The role of mitochondria dysfunction and hepatic senescence in NAFLD development and progression
SA Dabravolski, EE Bezsonov, AN Orekhov - Biomedicine & …, 2021 - Elsevier
Senescence is a crucial player in several metabolic disorders and chronic inflammatory
diseases. Recent data prove the involvement of hepatocyte senescence in the development …
diseases. Recent data prove the involvement of hepatocyte senescence in the development …
Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress
Mitochondrial dysfunction promotes metabolic stress responses in a cell‐autonomous as
well as organismal manner. The wasting hormone growth differentiation factor 15 (GDF 15) …
well as organismal manner. The wasting hormone growth differentiation factor 15 (GDF 15) …
Graves' disease: can it be cured?
WM Wiersinga - Endocrinology and Metabolism, 2019 - synapse.koreamed.org
Whether or not Graves' hyperthyroidism can be really cured, depends on the definition of
“cure.” If eradication of thyroid hormone excess suffices for the label “cure,” then all patients …
“cure.” If eradication of thyroid hormone excess suffices for the label “cure,” then all patients …
[HTML][HTML] Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive …
Neuronal oxidative stress has been implicated in aging and neurodegenerative disease.
Here we investigated the impact of elevated oxidative stress induced in mouse spinal cord …
Here we investigated the impact of elevated oxidative stress induced in mouse spinal cord …
Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response
Perturbation of mitochondrial proteostasis provokes cell autonomous and cell non-
autonomous responses that contribute to homeostatic adaptation. Here, we demonstrate …
autonomous responses that contribute to homeostatic adaptation. Here, we demonstrate …