Chemistry and biology of multicomponent reactions

A Domling, W Wang, K Wang - Chemical reviews, 2012 - ACS Publications
Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

Metal-free multicomponent syntheses of pyridines

C Allais, JM Grassot, J Rodriguez… - Chemical …, 2014 - ACS Publications
They react according to a succession of mono-or bimolecular processes to form at the end
one product that incorporates important portions and functionalities of the starting materials …

Recent applications of multicomponent reactions in medicinal chemistry

P Slobbe, E Ruijter, RVA Orru - MedChemComm, 2012 - pubs.rsc.org
Multicomponent reactions are flexible reactions for the rapid generation of complex
molecules with often biologically relevant scaffold structures. Combined with the ease of …

Imidazo[1,2-a]pyridines Susceptible to Excited State Intramolecular Proton Transfer: One-Pot Synthesis via an Ortoleva–King Reaction

AJ Stasyuk, M Banasiewicz, MK Cyrański… - The Journal of organic …, 2012 - ACS Publications
A short and efficient route to a broad range of imidazo [1, 2-a] pyridines from 2-
aminopyridines and acetophenones is achieved by a tandem, one-pot process starting with …

The Groebke‐Blackburn‐Bienaymé Reaction

A Boltjes, A Dömling - European Journal of Organic Chemistry, 2019 - Wiley Online Library
Imidazo [1, 2‐a] pyridine is a well‐known scaffold in many marketed drugs, such as
Zolpidem, Minodronic acid, Miroprofen and DS‐1 and it also serves as a broadly applied …

Pyrimidazole-based covalent organic frameworks: integrating functionality and ultrastability via isocyanide chemistry

J Liu, T Yang, ZP Wang, PL Wang, J Feng… - Journal of the …, 2020 - ACS Publications
Development of new chemistry to simultaneously meet the demands for topology,
connectivity, and functionality is highly desired in the research area of covalent organic …

Imidazo [1, 2-a] pyridine scaffold as prospective therapeutic agents

A Deep, R Kaur Bhatia, R Kaur, S Kumar… - Current topics in …, 2017 - ingentaconnect.com
Imidazo [1, 2-a] pyridine is one of the most potential bicyclic 5–6 heterocyclic rings that is
recognized as a “drug prejudice” scaffold due to its broad range of applications in medicinal …

Diversity-oriented synthesis of fused-imidazole derivatives via Groebke–Blackburn–Bienayme reaction: a review

N Devi, RK Rawal, V Singh - Tetrahedron, 2015 - Elsevier
In recent time, diversity-oriented synthesis of small chemical entities has been emerged as a
possible tool for exploring the intersections between chemistry and biology. These small …

Medicinal attributes of imidazo [1, 2-a] pyridine derivatives: an update

N Devi, D Singh, RK Rawal, J Bariwal… - Current topics in …, 2016 - ingentaconnect.com
The imidazo [1, 2-a] pyridine scaffold is recognized as a privileged structure as it represents
a promising area for identification of lead structures towards the discovery of new synthetic …

Recent Advances in the Synthesis of Imidazo[1,2‐a]pyridines: A Brief Review

J Panda, BP Raiguru, M Mishra, S Mohapatra… - …, 2022 - Wiley Online Library
This review focuses on providing comprehensive highlights of the recent synthetic pathways
of imidazo [1, 2‐a] pyridines, assisted through transition metal‐catalyzed reactions, multi …