Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty

C Badowski, B He, LX Garmire - NPJ precision oncology, 2022 - nature.com
Cancer ranks as one of the deadliest diseases worldwide. The high mortality rate associated
with cancer is partially due to the lack of reliable early detection methods and/or inaccurate …

NONCODEV6: an updated database dedicated to long non-coding RNA annotation in both animals and plants

L Zhao, J Wang, Y Li, T Song, Y Wu, S Fang… - Nucleic acids …, 2021 - academic.oup.com
Abstract NONCODE (http://www. noncode. org/) is a comprehensive database of collection
and annotation of noncoding RNAs, especially long non-coding RNAs (lncRNAs) in animals …

Pan-cancer characterization of immune-related lncRNAs identifies potential oncogenic biomarkers

Y Li, T Jiang, W Zhou, J Li, X Li, Q Wang, X Jin… - Nature …, 2020 - nature.com
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression
and they play fundamental roles in immune regulation. Here we introduce an integrated …

Long non-coding RNAs: the regulatory mechanisms, research strategies, and future directions in cancers

N Gao, Y Li, J Li, Z Gao, Z Yang, Y Li, H Liu… - Frontiers in …, 2020 - frontiersin.org
The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …

RNADisease v4. 0: an updated resource of RNA-associated diseases, providing RNA-disease analysis, enrichment and prediction

J Chen, J Lin, Y Hu, M Ye, L Yao, L Wu… - Nucleic Acids …, 2023 - academic.oup.com
Numerous studies have shown that RNA plays an important role in the occurrence and
development of diseases, and RNA-disease associations are not limited to noncoding RNAs …

RM2Target: a comprehensive database for targets of writers, erasers and readers of RNA modifications

X Bao, Y Zhang, H Li, Y Teng, L Ma… - Nucleic Acids …, 2023 - academic.oup.com
RNA modification is a dynamic and reversible process regulated by a series of writers,
erasers and readers (WERs). Abnormal changes of WERs will disrupt the RNA modification …

Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

[HTML][HTML] Non-coding RNA-mediated modulation of ferroptosis in cardiovascular diseases

Y Liu, W Ding, J Wang, X Ao, J Xue - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Cardiovascular disease (CVD) is a major contributor to increasing morbidity and mortality
worldwide and seriously threatens human health and life. Cardiomyocyte death is …

The bioinformatics toolbox for circRNA discovery and analysis

L Chen, C Wang, H Sun, J Wang, Y Liang… - Briefings in …, 2021 - academic.oup.com
Circular RNAs (circRNAs) are a unique class of RNA molecule identified more than 40 years
ago which are produced by a covalent linkage via back-splicing of linear RNA. Recent …