Sarcoma treatment in the era of molecular medicine
Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers.
Although constituting only 1% of all human malignancies, sarcomas represent the second …
Although constituting only 1% of all human malignancies, sarcomas represent the second …
Modeling neoplastic disease with spheroids and organoids
Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …
components contribute to the development, progression, and metastasization of disease …
Unraveling Ewing sarcoma tumorigenesis originating from patient-derived mesenchymal stem cells
A Sole, S Grossetête, M Heintzé, L Babin, S Zaïdi… - Cancer research, 2021 - AACR
Ewing sarcoma is characterized by pathognomonic translocations, most frequently fusing
EWSR1 with FLI1. An estimated 30% of Ewing sarcoma tumors also display genetic …
EWSR1 with FLI1. An estimated 30% of Ewing sarcoma tumors also display genetic …
[HTML][HTML] Novel insights into anticancer mechanisms of elesclomol: More than a prooxidant drug
J Gao, X Wu, S Huang, Z Zhao, W He, M Song - Redox Biology, 2023 - Elsevier
As an essential micronutrient for humans, the metabolism of copper is fine-tuned by
evolutionarily conserved homeostatic mechanisms. Copper toxicity occurs when its …
evolutionarily conserved homeostatic mechanisms. Copper toxicity occurs when its …
Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma
Shunya Ohmura1, 2, 3, Aruna Marchetto3, Martin F. Orth3, Jing Li1, 2, Susanne Jabar4, 5,
Andreas Ranft4, 5, Endrit Vinca1, 2, Katharina Ceranski1, 2, Martha J. Carreño‑Gonzalez1 …
Andreas Ranft4, 5, Endrit Vinca1, 2, Katharina Ceranski1, 2, Martha J. Carreño‑Gonzalez1 …
[HTML][HTML] Targeted and immuno-based therapies in sarcoma: mechanisms and advances in clinical trials
F Tang, Y Tie, YQ Wei, CQ Tu, XW Wei - Biochimica et Biophysica Acta …, 2021 - Elsevier
Sarcomas represent a distinct group of rare malignant tumors with high heterogeneity.
Limited options with clinical efficacy for the metastatic or local advanced sarcoma existed …
Limited options with clinical efficacy for the metastatic or local advanced sarcoma existed …
Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship
AK Ceranski, MJ Carreño-Gonzalez, AC Ehlers… - Molecular cancer, 2023 - Springer
Hypoxia develops during the growth of solid tumors and influences tumoral activity in
multiple ways. Low oxygen tension is also present in the bone microenvironment where …
multiple ways. Low oxygen tension is also present in the bone microenvironment where …
Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation
Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors
converting polymorphic GGAA microsatellites (mSats) into potent neo-enhancers. Although …
converting polymorphic GGAA microsatellites (mSats) into potent neo-enhancers. Although …
The importance of fusion protein activity in Ewing sarcoma and the cell intrinsic and extrinsic factors that regulate it: A review
AA Apfelbaum, ED Wrenn, ER Lawlor - Frontiers in oncology, 2022 - frontiersin.org
Accumulating evidence shows that despite clonal origins tumors eventually become
complex communities comprised of phenotypically distinct cell subpopulations. This …
complex communities comprised of phenotypically distinct cell subpopulations. This …
Targeted delivery of elesclomol using a magnetic mesoporous platform improves prostate cancer treatment both in vitro and in vivo
Background To improve the anticancer properties of elesclomol (ELC), targeted theranostic
nanoparticles (NPs; APT-PEG-Au-MMNPs@ ELC) were designed to increase the selectivity …
nanoparticles (NPs; APT-PEG-Au-MMNPs@ ELC) were designed to increase the selectivity …