Before a tooth erupts into the oral cavity, the mineralized enamel and dentin layers begin to
develop. During these early stages of enamel formation, an abundant group of proteins …

ALPL encodes the tissue nonspecific alkaline phosphatase (TNSALP), which removes
phosphate groups from various substrates. Its function is essential for bone and tooth …

Background Secondary edentulism (toothlessness) has evolved on multiple occasions in
amniotes including several mammalian lineages (pangolins, anteaters, baleen whales) …

Genetic approaches have shown that several genes could modify caries susceptibility;
AmelogeninX (AMELX) has been repeatedly designated. Here, we hypothesized that …

In this article, we focus on hypomaturation autosomal-recessive-type amelogenesis
imperfecta (type IIA2) and describe 2 new causal Matrix metalloproteinase 20 (MMP20) …

Enamelin (ENAM) plays an important role in the mineralization of the forming enamel matrix.
We have performed an evolutionary analysis of mammalian ENAM to identify highly …

This overview will examine the multifunctional nature of a group of proteins known as the
amelogenins. These secreted proteins were named in the 1960s because of their expected …

Molecular evolutionary analysis is an efficient method to predict and/or validate amino acid
substitutions that could lead to a genetic disease and to highlight residues and motifs that …

The abundant amelogenin proteins are responsible for generating proper enamel thickness
and structure, and most amelogenins include a conserved hydrophilic C-terminus. To …

Amelogenesis imperfecta (AI) designates a group of genetic diseases characterized by a
large range of enamel disorders causing important social and health problems. These …