Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Glycosylation is the stepwise procedure of covalent attachment of oligosaccharide chains to
proteins or lipids, and alterations in this process have been associated with malignant …

The cell surface displays a complex array of oligosaccharides, glycoproteins, and
glycolipids. This diverse mixture of glycans contains a wealth of information, modulating a …

Heparin is a highly sulfated, linear polymer that participates in a plethora of biological
processes by interaction with many proteins. The chemical complexity and heterogeneity of …

The heparan sulfate (HS) chains of heparan sulfate proteoglycans (HSPG) are “ubiquitous”
components of the cell surface and the extracellular matrix (EC) and play important roles in …

Glycosaminoglycans are sulfated biopolymers with rich chemical diversity and complex
functions in vivo, contributing to processes ranging from cell growth and neuronal …

Heparin, the drug of choice for the prevention and treatment of thromboembolic disorders,
has been shown to interact with many proteins. Despite its widespread medical use, little is …

The L-iduronic acid (IdoA) residue is a critically important structural component in heparan
sulphate polysaccharide for the biological functions. The pyranose ring of IdoA is present in …

Sulfated polysaccharides are capable of binding with proteins at several levels of specificity.
As highly acidic macromolecules, they can bind non-specifically to any basic patch on a …

Glycosaminoglycans represent a class of linear anionic periodic polysaccharides, which
play a key role in a variety of biological processes in the extracellular matrix via interactions …