Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

Interactions of electrogenic sodium-calcium exchange, calcium channel and sarcoplasmic
reticulum in the mammalian heart have been explored by simulation of extracellular calcium …

A mathematical model of the cardiac ventricular action potential is presented. In our previous
work, the membrane Na+ current and K+ currents were formulated. The present article …

BACKGROUND Experiments were performed in human ventricular myocytes to investigate
properties of excitation-contraction coupling in patients with terminal heart failure. Myocytes …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

We construct a detailed mathematical model for Ca 2+ regulation in the ventricular myocyte
that includes novel descriptions of subcellular mechanisms based on recent experimental …

The intracellular calcium ([Ca2+] i) transient in adult rat heart cells was examined using the
fluorescent calcium indicator fluo-3 and a laser scanning confocal microscope. We find that …

The Ca2+ sensitivities of the rate constant of tension redevelopment (ktr; Brenner, B., and E.
Eisenberg. 1986. Proceedings of the National Academy of Sciences. 83: 3542-3546) and …

Our aim was to measure the influence of sarcoplasmic reticulum (SR) calcium content ([Ca]
SRT) and free SR [Ca]([Ca] SR) on the fraction of SR calcium released during voltage clamp …

Experiments were carried out to compare the amplitude and time course of Ca2+ release
from the sarcoplasmic reticulum (SR) in intact slow‐twitch and fast‐twitch mouse fibres …