Glycosidases are ubiquitous enzymes that catalyze the hydrolysis of glycosidic linkages in
oligosaccharides and glycoconjugates. These enzymes play a vital role in a wide variety of …

In recent years, enzymes have risen as promising therapeutic tools for different pathologies,
from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint …

Abstract Background The Treatable ID App was created in 2012 as digital tool to improve
early recognition and intervention for treatable inherited metabolic disorders (IMDs) …

Background Nanomaterials are widely used as pesticide adjuvants to increase pesticide
efficiency and minimize environmental pollution. But it is increasingly recognized that …

Gangliosidoses are caused by monogenic defects of a specific hydrolase or an ancillary
sphingolipid activator protein essential for a specific step in the catabolism of gangliosides …

The lack of available treatments and fatal outcome in most lysosomal storage disorders
(LSDs) have spurred research on pathological mechanisms and novel therapies in recent …

Background Systemic lupus erythematosus (SLE) comprise a diverse range of clinical
manifestations. To date, more than 30 single gene causes of lupus/lupus like syndromes in …

Mutations in human genes might lead to the loss of functional proteins, causing diseases.
Among these genetic disorders, a large class is associated with the deficiency in metabolic …

An increase in total drug (small molecules and biologics) approvals by the Food and Drug
Administration (FDA) was seen in 2023 compared with the previous year. Cancer remained …

Dysregulation of glycosylation pathways has been well documented in several types of
cancer, where it often participates in cancer development and progression, especially …