Organic cation transporters in health and disease
H Koepsell, LC Daws - Pharmacological reviews, 2020 - Elsevier
The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
Transporters in drug development: 2018 ITC recommendations for transporters of emerging clinical importance
MJ Zamek‐Gliszczynski, ME Taub… - Clinical …, 2018 - Wiley Online Library
This white paper provides updated International Transporter Consortium (ITC)
recommendations on transporters that are important in drug development following the 3rd …
recommendations on transporters that are important in drug development following the 3rd …
Identification of drug transporter genomic variants and inhibitors that protect against doxorubicin-induced cardiotoxicity
Background: Multiple pharmacogenomic studies have identified the synonymous genomic
variant rs7853758 (G> A, L461L) and the intronic variant rs885004 in SLC28A3 (solute …
variant rs7853758 (G> A, L461L) and the intronic variant rs885004 in SLC28A3 (solute …
Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2
A wide range of endogenous and xenobiotic organic ions require facilitated transport
systems to cross the plasma membrane for their disposition. In mammals, organic cation …
systems to cross the plasma membrane for their disposition. In mammals, organic cation …
Transporter-mediated drug-drug interactions and their significance
X Liu - Drug Transporters in Drug Disposition, Effects and …, 2019 - Springer
Drug transporters are considered to be determinants of drug disposition and effects/toxicities
by affecting the absorption, distribution, and excretion of drugs. Drug transporters are …
by affecting the absorption, distribution, and excretion of drugs. Drug transporters are …
Clinical aspects of transporter‐mediated drug–drug interactions
Drug transporters play an essential role in disposition and effects of multiple drugs. Plasma
concentrations of the victim drug can be modified by drug–drug interactions occurring in …
concentrations of the victim drug can be modified by drug–drug interactions occurring in …
SLC family transporters
X Liu - Drug transporters in drug disposition, effects and …, 2019 - Springer
Solute carrier (SLC) family transporters utilize an electrochemical potential difference or an
ion gradient generated by primary active transporters for transporting their substrates across …
ion gradient generated by primary active transporters for transporting their substrates across …
Update on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advanced in vitro testing
H Koepsell - Expert Opinion on Drug Metabolism & Toxicology, 2021 - Taylor & Francis
Introduction: Organic cation transporters collectively called OCTs belong to three gene
families (SLC22A1 OCT1, SLC22A2 OCT2, SLC22A3 OCT3, SLC22A4 OCTN1, SLC22A5 …
families (SLC22A1 OCT1, SLC22A2 OCT2, SLC22A3 OCT3, SLC22A4 OCTN1, SLC22A5 …
Importance of hepatic transporters in clinical disposition of drugs and their metabolites
M Patel, KS Taskar… - The Journal of Clinical …, 2016 - Wiley Online Library
This review provides a practical clinical perspective on the relevance of hepatic transporters
in pharmacokinetics and drug‐drug interactions (DDIs). Special emphasis is placed on …
in pharmacokinetics and drug‐drug interactions (DDIs). Special emphasis is placed on …
[HTML][HTML] Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug–drug interactions
Metformin is used as a probe for OCT2 mediated transport when investigating possible DDIs
with new chemical entities. The aim of the current study was to investigate the ability of …
with new chemical entities. The aim of the current study was to investigate the ability of …