Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was
identified. Since that time, MYC research has been intense and the advances impressive …

Mounting evidence supports the presence of biologically relevant G‐quadruplexes in single‐
cell organisms, but the existence of endogenous G‐quadruplex structures in mammalian …

DNA in cells is predominantly B-form double helix. Though certain DNA sequences in vitro
may fold into other structures, such as triplex, left-handed Z form, or quadruplex DNA, the …

The importance of DNA supercoiling in transcriptional regulation has been known for many
years, and more recently, transcription itself has been shown to be a source of this …

MYC is deregulated in most tumour types, but an effective means to selectively target its
aberrant expression is not yet available. Supercoiling that is induced by transcription has …

Transcription has the capacity to mechanically modify DNA topology, DNA structure and
nucleosome arrangement. Resulting from ongoing transcription, these modifications in turn …

Dynamic molecular interactions play a central role in regulating the functioning of cells and
organisms. The availability of experimentally determined large-scale cellular networks …

Microsatellite repeat DNA is best known for its length mutability, which is implicated in
several neurological diseases and cancers, and often exploited as a genetic marker. Less …

Because RNA polymerase is a powerful motor, transmission of transcription-generated
forces might directly alter DNA structure, chromatin or gene activity in mammalian cells. Here …

Tandem repeats are genomic elements that are prone to changes in repeat number and are
thus often polymorphic. These sequences are found at a high density at the start of human …