Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets
S Dewanjee, S Das, AK Das, N Bhattacharjee… - European journal of …, 2018 - Elsevier
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …
The role of advanced glycation end products in progression and complications of diabetes
Context: Diabetic complications appear to be multifactorial in origin, but in particular, the
biochemical process of advanced glycation, which is accelerated in diabetes as a result of …
biochemical process of advanced glycation, which is accelerated in diabetes as a result of …
Diabetic neuropathy: mechanisms to management
JL Edwards, AM Vincent, HT Cheng… - Pharmacology & …, 2008 - Elsevier
Neuropathy is the most common and debilitating complication of diabetes and results in
pain, decreased motility, and amputation. Diabetic neuropathy encompasses a variety of …
pain, decreased motility, and amputation. Diabetic neuropathy encompasses a variety of …
Therapeutic applications of PARP inhibitors: anticancer therapy and beyond
The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …
Pleiotropic effects of statins: new therapeutic targets in drug design
The HMG Co-enzyme inhibitors and new lipid-modifying agents expand their new
therapeutic target options in the field of medical profession. Statins have been described as …
therapeutic target options in the field of medical profession. Statins have been described as …
[HTML][HTML] FBXW7 alleviates hyperglycemia-induced endothelial oxidative stress injury via ROS and PARP inhibition
S Li, J Deng, D Sun, S Chen, X Yao, N Wang, J Zhang… - Redox biology, 2022 - Elsevier
Diabetic retinopathy (DR) and other diabetic vascular complications are the leading cause of
death and disability in patients with suboptimum glycemic control. In the pathogenesis of …
death and disability in patients with suboptimum glycemic control. In the pathogenesis of …
Mouse models of diabetic neuropathy
PD O'Brien, SA Sakowski, EL Feldman - ILAR journal, 2014 - academic.oup.com
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and is
associated with significant morbidity and mortality. DPN is characterized by progressive …
associated with significant morbidity and mortality. DPN is characterized by progressive …
Antioxidant strategies in the management of diabetic neuropathy
Chronic hyperglycaemia (an abnormally high glucose concentration in the blood) resulting
from defects in insulin secretion/action, or both, is the major hallmark of diabetes in which it …
from defects in insulin secretion/action, or both, is the major hallmark of diabetes in which it …
[PDF][PDF] Diabetes and advanced glycoxidation end products
AG Huebschmann, JG Regensteiner, H Vlassara… - Diabetes …, 2006 - academia.edu
The morbidity caused by diabetes has traditionally been classified into macro-and
microvascular complications. Although macrovascular complications have received greater …
microvascular complications. Although macrovascular complications have received greater …
Mechanisms of disease: the oxidative stress theory of diabetic neuropathy
C Figueroa-Romero, M Sadidi, EL Feldman - Reviews in Endocrine and …, 2008 - Springer
Diabetic neuropathy is the most common complication of diabetes, affecting 50% of diabetic
patients. Currently, the only treatment for diabetic neuropathy is glucose control and careful …
patients. Currently, the only treatment for diabetic neuropathy is glucose control and careful …