Mitochondrial SIRT3 and neurodegenerative brain disorders
Sirtuins are highly conserved NAD+ dependent class III histone deacetylases and catalyze
deacetylation and ADP ribosylation of a number of non-histone proteins. Since, they require …
deacetylation and ADP ribosylation of a number of non-histone proteins. Since, they require …
Hyperammonaemia‐induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress
G Davuluri, A Allawy, S Thapaliya… - The Journal of …, 2016 - Wiley Online Library
Key points Hyperammonaemia occurs in hepatic, cardiac and pulmonary diseases with
increased muscle concentration of ammonia. We found that ammonia results in reduced …
increased muscle concentration of ammonia. We found that ammonia results in reduced …
Environmental ammonia exposure induces oxidative stress in gills and brain of Boleophthalmus boddarti (mudskipper)
This study aimed to elucidate whether exposure to a sublethal concentration (8mmoll− 1) of
NH4Cl (pH 7.0) for 12 or 48h would induce oxidative stress in gills and brain of the …
NH4Cl (pH 7.0) for 12 or 48h would induce oxidative stress in gills and brain of the …
Modulation of antioxidant enzymes, SIRT1 and NF‐κB by resveratrol and nicotinamide in alcohol‐aflatoxin B1‐induced hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the fifth most commonly diagnosed cancer worldwide
and is associated with poor prognosis. The current study aimed to assess the therapeutic …
and is associated with poor prognosis. The current study aimed to assess the therapeutic …
Profiling of oxidative stress in patients with inborn errors of metabolism
PJ Mc Guire, A Parikh, GA Diaz - Molecular genetics and metabolism, 2009 - Elsevier
Free radical formation resulting in oxidative stress is a hallmark of mitochondrial dysfunction.
Indeed, oxidative stress has been demonstrated to be an underlying pathophysiologic …
Indeed, oxidative stress has been demonstrated to be an underlying pathophysiologic …
The effects of Ibuprofen and 1, 8-cineol on anxiety and spatial memory in hyperammonemic rats
T Bahrami, P Yaghmaei, N Yousofvand - Metabolic Brain Disease, 2023 - Springer
In hepatic encephalopathy, hyperammonemia (HA) causes cognitive impairment and
anxiety by causing neuroinflammation. Ibuprofen and 1, 8-cineol have anti-inflammatory and …
anxiety by causing neuroinflammation. Ibuprofen and 1, 8-cineol have anti-inflammatory and …
High environmental ammonia elicits differential oxidative stress and antioxidant responses in five different organs of a model estuarine teleost (Dicentrarchus labrax)
We investigated oxidative status and antioxidant profile in five tissues (brain, liver, gills,
muscle and kidney) of European sea bass (Dicentrarchus labrax) when exposed to high …
muscle and kidney) of European sea bass (Dicentrarchus labrax) when exposed to high …
Activation of oxidative stress and inflammatory factors could account for histopathological progression of aflatoxin-B1 induced hepatocarcinogenesis in rat
Abstract Aflatoxin-B1 (AFB1) intoxication is known to develop hepatocellular carcinoma
(HCC). However, pathogenesis and diagnosis of AFB1-induced HCC remain undefined …
(HCC). However, pathogenesis and diagnosis of AFB1-induced HCC remain undefined …
Sirtuin‐3 activation by honokiol restores mitochondrial dysfunction in the hippocampus of the hepatic encephalopathy rat model of ammonia neurotoxicity
The neurotoxic level of ammonia in the brain during liver cirrhosis causes a nervous system
disorder, hepatic encephalopathy (HE), by affecting mitochondrial functions. Sirtuin‐3 …
disorder, hepatic encephalopathy (HE), by affecting mitochondrial functions. Sirtuin‐3 …
SIRT1 activation by resveratrol reverses atrophy of apical dendrites of hippocampal CA1 pyramidal neurons and neurobehavioral impairments in moderate grade …
A Khanna, S Chakraborty, SJ Tripathi… - Journal of chemical …, 2020 - Elsevier
A preliminary observation about resveratrol (RSV) dependent normalization of inflammatory
and apoptotic factors in the cortex of hyperammonemic rat model of moderate grade hepatic …
and apoptotic factors in the cortex of hyperammonemic rat model of moderate grade hepatic …