The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …

RNAs in cells are associated with RNA-binding proteins (RBPs) to form ribonucleoprotein
(RNP) complexes. The RBPs influence the structure and interactions of the RNAs and play …

From sites of transcription in the nucleus to the outreaches of the cytoplasm, messenger
RNAs are associated with RNA-binding proteins. These proteins influence pre-mRNA …

Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively
degrades mRNAs harboring premature termination (nonsense) codons. If translated, these …

Studies of nonsense-mediated mRNA decay in mammalian cells have proffered unforeseen
insights into changes in mRNA–protein interactions throughout the lifetime of an mRNA …

The transport of RNA molecules from the nucleus to the cytoplasm is fundamental for gene
expression. The different RNA species that are produced in the nucleus are exported …

Although it has been known since the late 1970s that intron-containing and intronless
versions of otherwise identical genes can exhibit dramatically different expression profiles …

Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNA
containing premature termination codons (PTCs). In mammalian cells, recognition of PTCs …

Increasing a protein concentration in solution to the required level, without causing
aggregation and precipitation is often a challenging but important task, especially in the field …

The exon junction complex (EJC) plays a major role in posttranscriptional regulation of
mRNA in metazoa. The EJC is deposited onto mRNA during splicing and is transported to …