GABA is the major inhibitory neurotransmitter that counterbalances excitation in the mature
brain. The inhibitory action of GABA relies on the inflow of chloride ions (Cl−), which …

Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the gene
encoding methyl-CpG-binding protein 2 (MeCP2). Almost two decades of research into RTT …

Intellectual disability, autism spectrum disorder, and epilepsy are prime examples of
neurodevelopmental disorders that collectively affect a significant percentage of the world …

γ-Aminobutyric acid (GABA), the main inhibitory neurotransmitter in the adult brain, early in
postnatal life exerts a depolarizing and excitatory action. This depends on accumulation of …

In physiological conditions, adult neurons have low intracellular Cl−[(Cl−) I] levels
underlying the γ-aminobutyric acid (GABA) ergic inhibitory drive. In contrast, neurons have …

Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …

Rett syndrome (RTT) arises from loss-of-function mutations in methyl-CpG binding protein 2
gene (Mecp2), but fundamental aspects of its physiological mechanisms are unresolved …

Delays in synaptic and neuronal development in the cortex are key hallmarks of fragile X
syndrome, a prevalent neurodevelopmental disorder that causes intellectual disability and …

Neuronal chloride regulation is a determinant factor for the dynamic tuning of GABAergic
inhibition during and beyond brain development. This regulation is mainly dependent on the …

During mammalian ontogenesis, the neurotransmitter GABA is a fundamental regulator of
neuronal networks. In neuronal development, GABAergic signaling regulates neural …