Structural changes on a broad range of length and time scales are closely connected to
biochemical function. The high relevance of conformational dynamics to macromolecular …

In contrast to B-DNA that has a right-handed double helical structure with Watson–Crick
base pairing under the ordinary physiological conditions, repetitive DNA sequences under …

This study describes a facile and general strategy for the development of aptamer-based
electrochemical sensors with a high specificity toward the targets and a ready regeneration …

Intramolecular chain diffusion is an elementary process in the conformational fluctuations of
the DNA hairpin-loop. We have studied the temperature and viscosity dependence of a …

Fluorescence correlation spectroscopy is a method in which fluctuations in the fluorescence
arising from a very small sample volume are correlated to obtain information about the …

Fluorescence correlation spectroscopy (FCS) has recently emerged as a powerful technique
to study conformational dynamics of biomolecules, but often its applicability is limited by the …

The interaction of human serum albumin (HSA), human holo transferrin (HTF), and
hemoglobin (Hb) with temporin Rb (TRb) were investigated using several spectroscopic and …

Analytical measurements at the single molecule level under ambient conditions have
become almost routine in the past few years. The application of this technology to …

Histograms of single-molecule Förster resonance energy transfer (FRET) efficiency are often
used to study the structures of biomolecules and relate these structures to function. Methods …

Elucidating the mechanism of folding of polynucleotides depends on accurate estimates of
free energy surfaces and a quantitative description of the kinetics of structure formation …