Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …

The cancer stem cell (CSC) hypothesis, despite the limitations of the currently available
models and assays, has ushered in a new era of excitement in cancer research. The …

Colorectal cancer (CRC) is one of the most commonly diagnosed and lethal cancers
worldwide. It is a multistep process that requires the accumulation of genetic/epigenetic …

Cancer stem cells are the cancer cells that have abilities to self-renew, differentiate into
defined progenies, and initiate and maintain tumor growth. They also contribute to cancer …

Colorectal cancer (CRC) is a major cause of cancer-related mortality in the world. Recently,
a number of studies have demonstrated that cancer stem cells (CSCs) present in colorectal …

Colorectal cancer is one of the most common malignant tumors worldwide. A model of
cancer development involving cancer stem cells has been put forward because it provides a …

Objective CD133 has recently been reported as a marker of cancer stem-like cells in
colorectal cancer (CRC). However, its predictive value in CRC still remains controversial. In …

Identification and reversal of treatment resistance mechanisms of clinically refractory tumor
cells is critical for successful cancer therapy. Here we show that ATP-binding cassette …

Abstract CD133 (prominin-1) is a member of the transmembrane glycoprotein family and
was initially described as a specific marker to select human hematopoietic progenitor cells …

Background Cancer stem-like cells (CSCs) in colorectal cancers (CRC) may account for the
failure of treatments because they are resistant to many current anticancer therapies …