Objective: To review recent advances in understanding the role of leptin in the physiology
and pathophysiology of reproduction, with a focus on relevant clinical situations. Design: A …

Integrative neuroendocrine control of the gonadotropic and somatotropic axes in childhood,
puberty, and young adulthood proceeds via multiple convergent and divergent pathways in …

This chapter discusses the modulatory influences regulating the timing of puberty in rats.
The developmental process that leads to puberty in the female rat is based on an …

Puberty in mammalian species is a period of rapid interactive endocrine and morphological
changes. Therefore, it is not surprising that exposure to a variety of pharmaceutical and …

Pubertal onset, initiated by pulsatile gonadotropin-releasing hormone (GnRH), only occurs
in a favorable, anabolic hormonal milieu. Anabolic factors that may signal nutritional status …

Data from epidemiological studies suggest that the decline in estrogen following
menopause could increase the risk of neurodegenerative diseases. Furthermore …

Background: Early menarche is a risk factor for cardiometabolic disease and cancer.
Latitude, which influences sun exposure, is inversely related to age at menarche. This …

Puberty is the developmental process that culminates in reproductive capability and is the
result of a complex series of molecular and physiological events. The release of …

The adolescent transition begins with the onset of puberty which, upstream in the brain, is
initiated by the gonadotropin‐releasing hormone (Gn RH) pulse generator that activates the …

The pubertal process is initiated as a result of complex neuroendocrine interactions within
the preoptic and hypothalamic regions of the brain. These interactions ultimately result in a …