GRP78: A cell's response to stress
Abstract Background Glucose-Regulated Protein 78 (GRP78) is a chaperone heat shock
protein that has been intensely studied in the last two decades. GRP78 is the master of the …
protein that has been intensely studied in the last two decades. GRP78 is the master of the …
[HTML][HTML] Obesity as a risk factor for severe COVID-19 and complications: a review
F Demeulemeester, K de Punder, M van Heijningen… - Cells, 2021 - mdpi.com
Emerging data suggest that obesity is a major risk factor for the progression of major
complications such as acute respiratory distress syndrome (ARDS), cytokine storm and …
complications such as acute respiratory distress syndrome (ARDS), cytokine storm and …
Natural products may interfere with SARS-CoV-2 attachment to the host cell
AA Elfiky - Journal of Biomolecular Structure and Dynamics, 2021 - Taylor & Francis
SARS-CoV-2 has been emerged in December 2019 in China, causing deadly (5% mortality)
pandemic pneumonia, termed COVID-19. More than one host-cell receptor is reported to be …
pandemic pneumonia, termed COVID-19. More than one host-cell receptor is reported to be …
[HTML][HTML] The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection
AJ Carlos, DP Ha, DW Yeh, R Van Krieken… - Journal of Biological …, 2021 - ASBMB
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
the COVID-19 global pandemic, utilizes the host receptor angiotensin-converting enzyme 2 …
the COVID-19 global pandemic, utilizes the host receptor angiotensin-converting enzyme 2 …
[HTML][HTML] Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development
Q Wan, D Song, H Li, M He - Signal transduction and targeted therapy, 2020 - nature.com
Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …
[HTML][HTML] Flavivirus receptors: diversity, identity, and cell entry
M Laureti, D Narayanan, J Rodriguez-Andres… - Frontiers in …, 2018 - frontiersin.org
Flaviviruses are emerging and re-emerging arthropod-borne pathogens responsible for
significant mortality and morbidity worldwide. The genus comprises more than seventy …
significant mortality and morbidity worldwide. The genus comprises more than seventy …
Pathobiology of Japanese encephalitis virus infection
Japanese encephalitis virus (JEV) is a flavivirus, spread by the bite of carrier Culex
mosquitoes. The subsequent disease caused is Japanese encephalitis (JE), which is the …
mosquitoes. The subsequent disease caused is Japanese encephalitis (JE), which is the …
[HTML][HTML] Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells
Coronavirus tropism is predominantly determined by the interaction between coronavirus
spikes and the host receptors. In this regard, coronaviruses have evolved a complicated …
spikes and the host receptors. In this regard, coronaviruses have evolved a complicated …
GRP78 targeting: Hitting two birds with a stone
AA Elfiky, AM Baghdady, SA Ali, MI Ahmed - Life sciences, 2020 - Elsevier
Background Glucose regulating protein 78 (GRP78) is one member of the Heat Shock
Protein family of chaperone proteins (HSPA5) found in eukaryotes. It acts as the master of …
Protein family of chaperone proteins (HSPA5) found in eukaryotes. It acts as the master of …
Pathogenesis and virulence of flavivirus infections
The Flavivirus genus consists of> 70 members including several that are considered
significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be …
significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be …