Tuberculous meningitis: pathogenesis, immune responses, diagnostic challenges, and the potential of biomarker-based approaches

CM Manyelo, RS Solomons, G Walzl… - Journal of clinical …, 2021 - Am Soc Microbiol
Tuberculous meningitis (TBM) is the most devastating form of tuberculosis (TB), causing
high mortality or disability. Clinical management of the disease is challenging due to …

[HTML][HTML] Tuberculous meningitis in children: reducing the burden of death and disability

J Huynh, YN Abo, K du Preez, R Solomons, KE Dooley… - Pathogens, 2021 - mdpi.com
Tuberculous meningitis disproportionately affects young children. As the most devastating
form of tuberculosis, it is associated with unacceptably high rates of mortality and morbidity …

[HTML][HTML] Tuberculous granuloma: emerging insights from proteomics and metabolomics

AR Sholeye, AA Williams, DT Loots… - Frontiers in …, 2022 - frontiersin.org
Mycobacterium tuberculosis infection, which claims hundreds of thousands of lives each
year, is typically characterized by the formation of tuberculous granulomas—the …

Randomized clinical trial of high-dose rifampicin with or without levofloxacin versus standard of care for pediatric tuberculous meningitis: the TBM-KIDS trial

MS Paradkar, B Devaleenal D, T Mvalo… - Clinical Infectious …, 2022 - academic.oup.com
Background Pediatric tuberculous meningitis (TBM) commonly causes death or disability. In
adults, high-dose rifampicin may reduce mortality. The role of fluoroquinolones remains …

[HTML][HTML] Analysis of tuberculosis meningitis pathogenesis, diagnosis, and treatment

A Arshad, S Dayal, R Gadhe, A Mawley, K Shin… - Journal of clinical …, 2020 - mdpi.com
Tuberculosis (TB) is the most prevalent infectious disease in the world. In recent years there
has been a significant increase in the incidence of TB due to the emergence of multidrug …

Pediatric and adult meningeal, parenchymal, and spinal tuberculosis: a neuroimaging review

L Mertiri, JT Freiling, NK Desai, SF Kralik… - Journal of …, 2024 - Wiley Online Library
Neurotuberculosis is defined as a tuberculous infection of the meninges, brain parenchyma,
vessels, cranial and spinal nerves, spinal cord, skull, and spine that can occur either in a …

Treatment outcomes and risk factors of death in childhood tuberculous meningitis in Kandahar, Afghanistan: a prospective observational cohort study

BA Rahimi, N Niazi, AF Rahimi… - Transactions of The …, 2022 - academic.oup.com
Background Tuberculous meningitis (TBM) is the most severe form of TB. We prospectively
documented the treatment outcomes and the risk factors for death in children with TBM from …

[HTML][HTML] The Role of Oxidative Stress in TB Meningitis and Therapeutic Options

J Dawi, AS Mohan, Y Misakyan, S Affa, E Gonzalez… - Diseases, 2024 - mdpi.com
Meningitis is an inflammatory condition affecting the meninges surrounding the brain and
spinal cord. Meningitis can be triggered by various factors, including infectious agents like …

Advances in tuberculous meningitis diagnosis

S Ahlawat, R Chaudhary, M Dangi, K Bala… - Expert Review of …, 2020 - Taylor & Francis
Introduction: Tuberculous meningitis (TBM) is the most devastating form of central nervous
system tuberculosis (TB) and causes high mortality worldwide. Nonspecific clinical …

[HTML][HTML] Patient characteristics and predictors of mortality among children hospitalised with tuberculosis: A six-year case series study in Uganda

PM Amuge, GL Becker, RN Ssebunya, E Nalumansi… - Plos one, 2024 - journals.plos.org
Background The high case-fatality rates among children with tuberculosis (TB) are
reportedly driven by in-hospital mortality and severe forms of TB. Therefore, there is need to …