Scorpion venom components that affect ion-channels function
V Quintero-Hernández, JM Jiménez-Vargas… - Toxicon, 2013 - Elsevier
The number and types of venom components that affect ion-channel function are reviewed.
These are the most important venom components responsible for human intoxication …
These are the most important venom components responsible for human intoxication …
[HTML][HTML] Epidemiological review of scorpion envenomation in Iran
This epidemiological review was carried out to display the magnitude and the geographic
distribution of scorpion envenomation in Iran with focus on the southwestern region of Iran …
distribution of scorpion envenomation in Iran with focus on the southwestern region of Iran …
Treating autoimmune disorders with venom-derived peptides
B Shen, Z Cao, W Li, JM Sabatier… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: The effective treatment of autoimmune diseases remains a challenge. Voltage-
gated potassium Kv1. 3 channels, which are expressed in lymphocytes, are a new …
gated potassium Kv1. 3 channels, which are expressed in lymphocytes, are a new …
[HTML][HTML] Variability of potassium channel blockers in Mesobuthus eupeus scorpion venom with focus on Kv1. 1: An integrated transcriptomic and proteomic study
AI Kuzmenkov, AA Vassilevski, KS Kudryashova… - Journal of biological …, 2015 - ASBMB
The lesser Asian scorpion Mesobuthus eupeus (Buthidae) is one of the most widely spread
and dispersed species of the Mesobuthus genus, and its venom is actively studied …
and dispersed species of the Mesobuthus genus, and its venom is actively studied …
Scorpion toxin peptide action at the ion channel subunit level
DM Housley, GD Housley, MJ Liddell, EA Jennings - Neuropharmacology, 2017 - Elsevier
This review categorizes functionally validated actions of defined scorpion toxin (SCTX)
neuropeptides across ion channel subclasses, highlighting key trends in this rapidly …
neuropeptides across ion channel subclasses, highlighting key trends in this rapidly …
[HTML][HTML] Molecular diversity and functional evolution of scorpion potassium channel toxins
S Zhu, S Peigneur, B Gao, L Luo, D Jin, Y Zhao… - Molecular & Cellular …, 2011 - ASBMB
Scorpion toxins affecting K+ channels (KTxs) represent important pharmacological tools and
potential drug candidates. Here, we report molecular characterization of seven new KTxs in …
potential drug candidates. Here, we report molecular characterization of seven new KTxs in …
[HTML][HTML] Electrophysiological Characterization of Ts6 and Ts7, K+ Channel Toxins Isolated through an Improved Tityus serrulatus Venom Purification Procedure
FA Cerni, MB Pucca, S Peigneur, CM Cremonez… - Toxins, 2014 - mdpi.com
In Brazil, Tityus serrulatus (Ts) is the species responsible for most of the scorpion related
accidents. Among the Ts toxins, the neurotoxins with action on potassium channels (α-KTx) …
accidents. Among the Ts toxins, the neurotoxins with action on potassium channels (α-KTx) …
[HTML][HTML] Scorpion toxins targeting Kv1. 3 channels: insights into immunosuppression
IS Oliveira, IG Ferreira, GM Alexandre-Silva… - Journal of Venomous …, 2019 - SciELO Brasil
Scorpion venoms are natural sources of molecules that have, in addition to their toxic
function, potential therapeutic applications. In this source the neurotoxins can be found …
function, potential therapeutic applications. In this source the neurotoxins can be found …
[HTML][HTML] Venoms of Iranian scorpions (Arachnida, Scorpiones) and their potential for drug discovery
SM Kazemi, JM Sabatier - Molecules, 2019 - mdpi.com
Scorpions, a characteristic group of arthropods, are among the earliest diverging arachnids,
dating back almost 440 million years. One of the many interesting aspects of scorpions is …
dating back almost 440 million years. One of the many interesting aspects of scorpions is …
[HTML][HTML] Venom-derived peptide modulators of cation-selective channels: friend, foe or frenemy
S Bajaj, J Han - Frontiers in pharmacology, 2019 - frontiersin.org
Ion channels play a key role in our body to regulate homeostasis and conduct electrical
signals. With the help of advances in structural biology, as well as the discovery of numerous …
signals. With the help of advances in structural biology, as well as the discovery of numerous …