Scorpion venom components that affect ion-channels function

V Quintero-Hernández, JM Jiménez-Vargas… - Toxicon, 2013 - Elsevier
The number and types of venom components that affect ion-channel function are reviewed.
These are the most important venom components responsible for human intoxication …

[HTML][HTML] Epidemiological review of scorpion envenomation in Iran

A Jalali, F Rahim - Iranian journal of pharmaceutical research …, 2014 - ncbi.nlm.nih.gov
This epidemiological review was carried out to display the magnitude and the geographic
distribution of scorpion envenomation in Iran with focus on the southwestern region of Iran …

Treating autoimmune disorders with venom-derived peptides

B Shen, Z Cao, W Li, JM Sabatier… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: The effective treatment of autoimmune diseases remains a challenge. Voltage-
gated potassium Kv1. 3 channels, which are expressed in lymphocytes, are a new …

[HTML][HTML] Variability of potassium channel blockers in Mesobuthus eupeus scorpion venom with focus on Kv1. 1: An integrated transcriptomic and proteomic study

AI Kuzmenkov, AA Vassilevski, KS Kudryashova… - Journal of biological …, 2015 - ASBMB
The lesser Asian scorpion Mesobuthus eupeus (Buthidae) is one of the most widely spread
and dispersed species of the Mesobuthus genus, and its venom is actively studied …

Scorpion toxin peptide action at the ion channel subunit level

DM Housley, GD Housley, MJ Liddell, EA Jennings - Neuropharmacology, 2017 - Elsevier
This review categorizes functionally validated actions of defined scorpion toxin (SCTX)
neuropeptides across ion channel subclasses, highlighting key trends in this rapidly …

[HTML][HTML] Molecular diversity and functional evolution of scorpion potassium channel toxins

S Zhu, S Peigneur, B Gao, L Luo, D Jin, Y Zhao… - Molecular & Cellular …, 2011 - ASBMB
Scorpion toxins affecting K+ channels (KTxs) represent important pharmacological tools and
potential drug candidates. Here, we report molecular characterization of seven new KTxs in …

[HTML][HTML] Electrophysiological Characterization of Ts6 and Ts7, K+ Channel Toxins Isolated through an Improved Tityus serrulatus Venom Purification Procedure

FA Cerni, MB Pucca, S Peigneur, CM Cremonez… - Toxins, 2014 - mdpi.com
In Brazil, Tityus serrulatus (Ts) is the species responsible for most of the scorpion related
accidents. Among the Ts toxins, the neurotoxins with action on potassium channels (α-KTx) …

[HTML][HTML] Scorpion toxins targeting Kv1. 3 channels: insights into immunosuppression

IS Oliveira, IG Ferreira, GM Alexandre-Silva… - Journal of Venomous …, 2019 - SciELO Brasil
Scorpion venoms are natural sources of molecules that have, in addition to their toxic
function, potential therapeutic applications. In this source the neurotoxins can be found …

[HTML][HTML] Venoms of Iranian scorpions (Arachnida, Scorpiones) and their potential for drug discovery

SM Kazemi, JM Sabatier - Molecules, 2019 - mdpi.com
Scorpions, a characteristic group of arthropods, are among the earliest diverging arachnids,
dating back almost 440 million years. One of the many interesting aspects of scorpions is …

[HTML][HTML] Venom-derived peptide modulators of cation-selective channels: friend, foe or frenemy

S Bajaj, J Han - Frontiers in pharmacology, 2019 - frontiersin.org
Ion channels play a key role in our body to regulate homeostasis and conduct electrical
signals. With the help of advances in structural biology, as well as the discovery of numerous …