The SARS-CoV-2 spike glycoprotein biosynthesis, structure, function, and antigenicity: implications for the design of spike-based vaccine immunogens
L Duan, Q Zheng, H Zhang, Y Niu, Y Lou… - Frontiers in …, 2020 - frontiersin.org
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …
HIV-1 vaccines based on antibody identification, B cell ontogeny, and epitope structure
PD Kwong, JR Mascola - Immunity, 2018 - cell.com
HIV-1 vaccine development has been stymied by an inability to induce broadly reactive
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
Beyond shielding: the roles of glycans in the SARS-CoV-2 spike protein
The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has resulted in more than 28,000,000 infections and 900,000 …
coronavirus 2 (SARS-CoV-2) has resulted in more than 28,000,000 infections and 900,000 …
Site-specific glycan analysis of the SARS-CoV-2 spike
The emergence of the betacoronavirus, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), represents a …
(SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), represents a …
SARS-CoV-2 spreads through cell-to-cell transmission
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
coronavirus responsible for the global COVID-19 pandemic. Herein, we provide evidence …
coronavirus responsible for the global COVID-19 pandemic. Herein, we provide evidence …
Learning the language of viral evolution and escape
The ability for viruses to mutate and evade the human immune system and cause infection,
called viral escape, remains an obstacle to antiviral and vaccine development …
called viral escape, remains an obstacle to antiviral and vaccine development …
ScanNet: an interpretable geometric deep learning model for structure-based protein binding site prediction
Predicting the functional sites of a protein from its structure, such as the binding sites of small
molecules, other proteins or antibodies, sheds light on its function in vivo. Currently, two …
molecules, other proteins or antibodies, sheds light on its function in vivo. Currently, two …
Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS)
coronaviruses (CoVs) are zoonotic pathogens with high fatality rates and pandemic …
coronaviruses (CoVs) are zoonotic pathogens with high fatality rates and pandemic …
[HTML][HTML] Unexpected receptor functional mimicry elucidates activation of coronavirus fusion
Recent outbreaks of severe acute respiratory syndrome and Middle East respiratory
syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the …
syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the …
Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein
X Fan, D Cao, L Kong, X Zhang - Nature communications, 2020 - nature.com
Global emergencies caused by the severe acute respiratory syndrome coronavirus (SARS-
CoV), Middle-East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV-2 …
CoV), Middle-East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV-2 …