Significance: Limited oxygen availability (hypoxia) commonly occurs in a range of
physiological and pathophysiological conditions, including embryonic development …

The perception of sepsis has shifted over time; however, it remains a leading cause of death
worldwide. Sepsis is now recognized as an imbalance in host cellular functions triggered by …

Background Early diagnosis of sepsis in children was essential to reducing mortality. This
study aimed to explore the value of ferroptosis-related genes in children with sepsis …

Metabolic adaptations shape immune cell function. In the acute response, a metabolic
switch towards glycolysis is necessary for mounting a proinflammatory response. During the …

Objective: Sepsis is a complex disease characterized by an inflammatory response and
tissue hypoxia. Hypoxia-inducible factor 1α (HIF-1α) expression level is regulated by …

Abstract N6-Methyladenosine (m6A) RNA methylation involves in regulating the initiation,
progression and aggravation of cerebral ischemia-reperfusion (I/R) injury, however, the …

Background Sepsis not only causes inflammation, but also damages the heart and
increases the risk of death. The glycolytic pathway plays a crucial role in the pathogenesis of …

Background Sepsis is a life-threatening organ dysfunction, which seriously threatens human
health. The clinical and experimental results have confirmed that Traditional Chinese …

The immune system in humans is a defense department against both exogenous and
endogenous hazards, where CD8+ T cells play a crucial role in opposing pathological …

Hypoxia is characterized as one of the main consequences of sepsis, which is recognized
as the leading cause of death in intensive care unit (ICU) patients. In this study, we aimed to …