Transforming growth factor-β (TGF-β) is a central regulator in chronic liver disease
contributing to all stages of disease progression from initial liver injury through inflammation …

Radiation therapy has curative or palliative potential in roughly half of all incident solid
tumours, and offers organ and function preservation in most cases. Unfortunately, early and …

Purpose: Immunotherapy using vaccines or adoptively transferred tumor-infiltrating
lymphocytes (TIL) is limited by T-cell functional inactivation within the solid tumor …

Bone is the most common site of metastasis for breast cancer. Bone metastasis significantly
affects both quality of life and survival of the breast cancer patient. Clinically, complications …

Advanced non-small cell lung cancer (NSCLC) continues to be an incurable family of
thoracic malignancies that is chronically managed with chemotherapy, targeted therapy, and …

Transforming growth factor-β (TGF-β) is a key player in malignant disease through its actions
on host tissues and cells. Malignant cells often secrete large amounts of TGF-β that act on …

The last decade has seen an explosion in knowledge of the molecular basis and treatment
of cancer. The molecular events that define the lethal phenotype of various cancers—the …

Simple Summary Transforming growth factor β (TGF-β) signaling is a preeminent regulator
of diverse cellular and physiological processes. Frequent dysregulation of TGF-β signaling …

The completely assembled human genome has made it possible for modern medicine to
step into an era rich in genetic information and high-throughput genomic analysis. These …

In diabetes and hypertension, the induction of increased transforming growth factor-β (TGF-
β) activity due to glucose and angiotensin II is a significant factor in the development of …