Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Cells can respond to stress in various ways ranging from the activation of survival pathways
to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a …

Mutations in phosphatase and tensin homologue‐induced kinase 1 (PINK1) cause
recessively inherited Parkinson's disease (PD), a neurodegenerative disorder linked to …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized
by the degeneration of dopamine (DA) and non-DA neurons, the almost uniform presence of …

Neurodegenerative diseases selectively target subpopulations of neurons, leading to the
progressive failure of defined brain systems, but the basis of such selective neuronal …

Abstract Parkinson's disease (PD), one of the most frequent neurodegenerative disorders, is
no longer considered a complex motor disorder characterized by extrapyramidal symptoms …

Genetic studies have provided valuable insight into the pathological mechanisms underlying
Parkinson's disease (PD). The elucidation of genetic components to what was once largely …

Polyphenols are secondary metabolites with antioxidant properties and are abundant in the
diet. Fruits, vegetables, herbs, and various drinks (tea, wine, and juices) are all sources of …

Disruption of the most fundamental cellular energy process, the mitochondrial respiratory
chain, results in a diverse and variable group of multisystem disorders known collectively as …

A promising approach to neurotherapeutics involves activating the nuclear-factor-E2-related
factor 2 (Nrf2)/antioxidant response element signaling, which regulates expression of …