Naphthalene, a versatile platform in medicinal chemistry: sky-high perspective
Naphthalene, a cytotoxic moiety, is an extensively explored aromatic conjugated system with
applications in various pathophysiological conditions viz. anticancer, antimicrobial, anti …
applications in various pathophysiological conditions viz. anticancer, antimicrobial, anti …
Glutamic acid and its derivatives: candidates for rational design of anticancer drugs
Throughout the history of human civilizations, cancer has been a major health problem. Its
treatment has been interesting but challenging to scientists. Glutamic acid and its derivative …
treatment has been interesting but challenging to scientists. Glutamic acid and its derivative …
Design, synthesis, spectroscopic characterizations, in vitro pancreatic lipase as well as tyrosinase inhibition evaluations and in silico analysis of novel aryl sulfonate …
One of the primary purposes of this study is to synthesize new aryl sulfonate-naphthalene
hybrid structures possessing divergent electron-withdrawing and electron-releasing …
hybrid structures possessing divergent electron-withdrawing and electron-releasing …
Synthesis and biological evaluation of new naphthalene substituted thiosemicarbazone derivatives as potent antifungal and anticancer agents
Abstract New thiosemicarbazone derivatives (1–10) were obtained via the reaction of 4-
(naphthalen-1-yl) thiosemicarbazide with fluoro-substituted aromatic aldehydes. The …
(naphthalen-1-yl) thiosemicarbazide with fluoro-substituted aromatic aldehydes. The …
Electrotopological state atom (E-state) index in drug design, QSAR, property prediction and toxicity assessment
K Roy, I Mitra - Current computer-aided drug design, 2012 - ingentaconnect.com
Over the last two decades, a great deal of research has been oriented towards
determination of correlation between molecular structures and a variety of responses …
determination of correlation between molecular structures and a variety of responses …
Synthesis of 5-hydroxyisatin thiosemicarbazones, spectroscopic investigation, protein-ligand docking, and in vitro anticancer activity
U Chaudhary, P Kumar, P Sharma, A Chikara… - Bioorganic …, 2024 - Elsevier
A series of novel modifications were performed at the N (4) position of 5-hydroxyisatin
thiosemicarbazone (TSC). The structure–activity approach is applied to design and …
thiosemicarbazone (TSC). The structure–activity approach is applied to design and …
Nanoparticle engineering enhances anticancer efficacy of andrographolide in MCF-7 cells and mice bearing EAC
Success in cancer chemotherapy relies on efficient delivery of anti-neoplastic drugs, with
minimal side-effects on non-cancerous cells. Nanoparticulation of prospective anti-cancer …
minimal side-effects on non-cancerous cells. Nanoparticulation of prospective anti-cancer …
Design, synthesis and biological evaluation of benzohydrazide derivatives containing dihydropyrazoles as potential EGFR kinase inhibitors
HC Wang, XQ Yan, TL Yan, HX Li, ZC Wang, HL Zhu - Molecules, 2016 - mdpi.com
A series of novel benzohydrazide derivatives containing dihydropyrazoles have been
synthesized as potential epidermal growth factor receptor (EGFR) kinase inhibitors and their …
synthesized as potential epidermal growth factor receptor (EGFR) kinase inhibitors and their …
Design and evaluation of novel oxadiazole derivatives as potential prostate cancer agents
B Mochona, X Qi, S Euynni, D Sikazwi… - Bioorganic & medicinal …, 2016 - Elsevier
Abstract Various 1, 3, 4-oxadiazole derivatives have been synthesized and their
antiproliferative properties have been studied. The in vitro screening was performed against …
antiproliferative properties have been studied. The in vitro screening was performed against …
Anti-cancer drug development: computational strategies to identify and target proteins involved in cancer metabolism
L Mak, S Liggi, L Tan, K Kusonmano… - Current …, 2013 - benthamdirect.com
Cancer remains a fundamental burden to public health despite substantial efforts aimed at
developing effective chemotherapeutics and significant advances in chemotherapeutic …
developing effective chemotherapeutics and significant advances in chemotherapeutic …